Open Access
ARTICLE
Ruben Willems1,*, Fouke Ombelet2, Eva Goossens2,3,4, Katya De Groote5, Werner Budts6,7, Stéphane Moniotte8, Michèle de Hosson9, Liesbet Van Bulck2,4, Arianne Marelli10, Philip Moons2,11,12, Julie De Backer4,9,#, Lieven Annemans1,#
Congenital Heart Disease, Vol.15, No.6, pp. 399-429, 2020, DOI:10.32604/CHD.2020.011709
Abstract Objective: Cost-of-illness studies in Adult Congenital Heart Disease
(ACHD) have mainly been limited to hospitalizations. This is the first paper to
provide a comprehensive overview from a societal perspective including inpatient
and outpatient medical costs, and absenteeism- and unemployment-related societal costs. Methods: A retrospective longitudinal (2006–2015) database analysis
was performed in Belgium combining administrative and clinical databases
(n = 10,572). Trends in resource use and costs per patient year were standardized
to assess the impact of changes in the patient population composition. Generalized
Linear Mixed Models assessed the impact of age, sex, lesion complexity, and
time. Costs were converted to… More >
Open Access
ARTICLE
Gang Li, Han Zhang, Yao Yang, Yang Liu, Aijun Liu, Xiangming Fan, Pei Cheng, Junwu Su*
Congenital Heart Disease, Vol.15, No.6, pp. 431-439, 2020, DOI:10.32604/CHD.2020.012249
Abstract Background: Pseudoaneurysm complicating right ventricular outflow
tract (RVOT) with conduit placement was an infrequent complication but with
potential for significant morbidity and mortality, and a more unusual pseudoaneurysm after RVOT patching was investigated here. Methods: Patients diagnosed as pseudoaneurysms at our institution from 2010 to 2019 were reviewed
and their clinical characteristics were analyzed. Results: A total of seven patients
developed pseudoaneurysm in RVOT were identified. One pseudoaneurysm arose
after placement of a conduit between the right ventricle and the pulmonary artery,
and the other six formed after RVOT patching. One patient presented with
arrhythmia, one patient had the pseudoaneurysm… More >
Open Access
CASE REPORT
Domenico Sirico1, Biagio Castaldi1,*, Giuseppe Tarantini2, Giovanni Di Salvo1
Congenital Heart Disease, Vol.15, No.6, pp. 441-445, 2020, DOI:10.32604/CHD.2020.012863
Abstract Asymptomatic coronary artery obstruction represents a significant diagnostic challenge in patients with Dextro-Transposition of the Great Arteries and
history of Arterial Switch Operation. We report the case of a 17-year-old boy with
anomalous origin of left circumflex artery from the right coronary artery, who
underwent neonatal arterial switch operation and developed silent myocardial
ischemia under stress on myocardial scintigraphy. Despite coronary angiogram
and intravascular ultrasound showed only intermediate stenosis of the right coronary artery ostium, the physiological analysis, through the employment of pressure
wire, demonstrated a severe reduction of coronary fractional flow reserve after
pharmacologically induced hyperemia. Thus, the patient… More >
Open Access
META-ANALYSIS
Rohit S. Loomba1,2, Enrique G. Villarreal3,*, Riddhi Patel1, Samantha Udarbe1, Vincent Dorsey1, Kristen Nelson-McMillan1,4, Saul Flores5,6
Congenital Heart Disease, Vol.15, No.6, pp. 447-455, 2020, DOI:10.32604/CHD.2020.012927
Abstract Introduction: In children, data on the effects on carnitine supplementation and myocardial function are limited. A few studies have investigated the
relationship between serum carnitine levels in the setting of depressed cardiac
function and have demonstrated possible benefits. As such, this systematic review
and meta-analyses aimed to assess the effects carnitine supplementation on left
ventricular function. Materials and Methods: A systematic review of the literature was performed to identify full text manuscripts in English. PubMed,
EMBASE, and the Cochrane databases were queried. Studies were included with
data from pediatric patients, that used carnitine supplementation and included preand post-carnitine data for… More >
Open Access
ARTICLE
Lianne M. Geerdink1,2,*, Malindi van der Mheen3,4, Gideon J. du Marchie Sarvaas5, Irene M. Kuipers6, Stefan Frerich7, Henriëtte ter Heide2, Willem A. Helbing8, Zina Feijzic1, Christian Schroer9, Chris L. de Korte10, Livia Kapusta1,11, Chris M. Verhaak12, Elisabeth M. W. J. Utens3,4
Congenital Heart Disease, Vol.15, No.6, pp. 457-472, 2020, DOI:10.32604/CHD.2020.012994
Abstract Background: Due to the improved survival rates of children and adolescents with congenital heart disease (CHD), more attention is now being directed towards their health-related quality of life (HRQoL), emotional and behavioral
problems. Ebstein anomaly (EA) is a rare CHD with a broad clinical spectrum.
The aim of the current study is to evaluate self- and proxy-reported HRQoL
and emotional and behavioral problems in children and adolescents with EA.
Methods: In this cross-sectional, multicenter study, we included EA patients
(aged 8–17 years), who underwent routine clinical assessments in Dutch university hospitals between May 2017 and March 2019. The Generic Pediatric… More >
Open Access
ARTICLE
Yoann Perreux1, Marie Alexandre Chaix2, Anna Kamp3, François-Pierre Mongeon2, Magali Pham2, Loïc Boussel1, Roland Henaine1, Annie Dore2, Blandine Mondésert2, Sylvie Di-Filippo1, Paul Khairy2, Francis Bessiere1,*
Congenital Heart Disease, Vol.15, No.6, pp. 473-482, 2020, DOI:10.32604/CHD.2020.013032
Abstract Sudden cardiac death and heart failure are well known long-term complications after atrial switch for D-transposition of the great arteries (D-TGA).
Right systemic ventricular dysfunction is common and myocardial ischemia has
been implicated as a putative mechanism for sudden death, with coronary anomalies prevalent in 30% of cases. We sought to assess an association between
adverse events and coronary anomalies in patients with D-TGA and atrial switch
surgery. An observational study was conducted in 3 tertiary centers (Montreal
Heart Institute, Canada, Nationwide Children’s hospital, Chicago, USA and Hopital cardiologique Louis Pradel de Lyon, France). Adults with D-TGA and atrial
switch… More >
Open Access
ARTICLE
Masataka Ogiso1,2, Kei Inai1,*, Morio Shoda2, Nobuhisa Hagiwara2, Hisashi Sugiyama1
Congenital Heart Disease, Vol.15, No.6, pp. 483-493, 2020, DOI:10.32604/CHD.2020.013058
Abstract Background: Pulmonary hypertension (PH) is one of the complications that can occur after the atrial switch procedure for transposition of the great
arteries (TGA). This study aimed to assess the characteristics and prognosis
of late-onset PH after the atrial switch procedure using catheterization data.
Methods and Results: We retrospectively identified 40 patients with TGA after
the atrial switch procedure that underwent catheterization between April 2007 and
March 2020. Eligible patients were divided into two groups based on PH presence
(PH group, n = 13 [33%]; non-PH group, n = 27 [67%]). Adverse events were
defined as cardiac death and heart… More >
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