@Article{CHD.2020.011575,
AUTHOR = {Alejandro E. Contreras, Alejandro R. Peirone, Eduardo Cuestas},
TITLE = {Cardiac Troponin Levels after Percutaneous Atrial Septal Defect Closure: A Qualitative Systematic Review and Meta-Analysis},
JOURNAL = {Congenital Heart Disease},
VOLUME = {15},
YEAR = {2020},
NUMBER = {1},
PAGES = {13--20},
URL = {http://www.techscience.com/chd/v15n1/39374},
ISSN = {1747-0803},
ABSTRACT = {Introduction: We conducted a systematic review and meta-analysis of
published studies to determine the prevalence of troponin elevation after
percutaneous atrial septal defect closure (pASDc) as well as to describe the
association between troponin elevation and different anatomical risk factors for
erosion. Methods: A qualitative systematic review and meta-analysis was
undertaken. The selected studies included patients of any age receiving a pASDc;
performed under transesophageal echocardiography monitoring; reporting
troponin level measurement after the intervention; and indicating prevalence of
troponin elevation and/or the association with risk factors for erosion. Results: Six
studies were found which included 391 patients in total. The age of the patients
ranged from 1 to 80 years and were mainly female (between 59 and 81%). The
success rate of pASDc varied from 92–100%. The prevalence of myocardial injury
varied between 16% and 100%. In the meta-analysis cohort including 347 patients
with available data, the fixed effect model showed a prevalence of 41.8% CI (95%)
36.6% to 47.2%. Five studies found a relationship between the size of the
implanted device and the presence of myocardial injury. The size of the defect,
multiple defects within the interatrial septum, deficient posterior rim, lack of use
of sizing balloon and longest duration of the procedure were also related to
myocardial injury. Conclusion: The usefulness of troponin levels measurements
after pASDc has been insufficiently studied. The routinely use in a standardized
protocol would be useful to determine which patients need a closer follow-up.},
DOI = {10.32604/CHD.2020.011575}
}