Open Access

ARTICLE

The incidence of arrhythmias during exercise stress tests among children with Kawasaki disease: A single-center case series

Varun Aggarwal^1,2, Kristen Sexson-Tejtal¹, Wilson Lam¹, Santiago O. Valdes¹, Caridad M. de la Uz¹, Jeffrey J. Kim¹, Christina Y. Miyake¹

1 The Lillie Frank Abercrombie Section of Cardiology, Department of Pediatric Cardiology, Texas Children’s Hospital and Baylor College of Medicine, Houston, Texas
2 Department of Pediatrics, Division of Pediatric Cardiology, Masonic Children’s Hospital, University of Minnesota, Minneapolis, Minnesota

* Corresponding Author: Christina Y. Miyake, The Lillie Frank Abercrombie Section of Cardiology, Department of Pediatric Cardiology, Texas Children’s Hospital, 6651 Main St, Legacy Tower, Suite# E1960.22, Houston, TX 77030, USA. Email:

Congenital Heart Disease 2019, 14(6), 1032-1036. https://doi.org/10.1111/chd.12864

Abstract

Objective: Based on 2017 guidelines, participation in competitive sports with prior history of Kawasaki Disease (KD) requires those with coronary artery aneurysms (CAA) z score ≥ 5 to undergo evaluation for evidence of inducible ischemia or arrhythmias. The use of exercise stress testing (EST) to evaluate arrhythmias among KD patients has never been reported. This retrospective single-center case series study sought to describe the presence of inducible arrhythmias during EST in KD patients with or without CAA.
Methods: Single-center retrospective review of medical records of patients diagnosed with KD between 1989-2015 at Texas Children’s Hospital, Houston, Texas who underwent EST were included.
Results: Among 1007 patients diagnosed with KD, 95 (9%) underwent 165 ESTs at a median time of 9.6 years (IQR 5.8-11.3 years) from diagnosis. Of these 95 patients, 37 had normal coronaries, 21 dilated (z score 2 to <2.5), 10 small (5 >z ≥2.5), 12 medium (10>z ≥ 5 absolute dimension <8 mm), 10 large (z ≥10 or absolute dimension ≥8 mm), 5 severe (myocardial infarct or bypass graft). Supraventricular tachycardia was not seen. Ventricular arrhythmias during EST were uncommon and seen only among patients with CAA z ≥5. Ventricular tachycardia occurred in a single patient with a large CAA, known VT and ICD. High-grade ventricular ectopy was seen in one patient who had severe CAA and underwent bypass grafting.
Conclusions: Arrhythmias on EST were noted only among patients with CAA z ≥5. The current guidelines are a reasonable approach to increasing healthy activity among KD patients. Clarification regarding which inducible arrhythmias meet criteria for activity restriction may be helpful to guide sport participation.

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