Open Access

ARTICLE

Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury

Dana Y. Fuhrman^1,2, Lan Nguyen³, Morgan Hindes³, John A. Kellum²

1 Department of Critical Care Medicine, The Center for Critical Care Nephrology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
2 Department of Critical Care Medicine, University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
3 Department of Pediatrics, Division of Pediatric Cardiology, The Center for Critical Care Nephrology, University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania

* Corresponding Author: Dana Y. Fuhrman, Department of Critical Care Medicine, University of Pittsburgh Children’s Hospital of Pittsburgh, 4401 Penn Avenue, Children’s Hospital Drive, Faculty Pavilion, Suite 2000, Pittsburgh, PA 15224. Email:

Congenital Heart Disease 2019, 14(6), 963-967. https://doi.org/10.1111/chd.12862

Abstract

Background: There are significant implications for kidney disease in young adults with congenital heart disease. Prior investigations have not focused on the use of urinary tubular biomarkers for the early identification of kidney disease in this growing patient group.
Objective: Determine if young adults with congenital heart disease have differences in the baseline concentration of urinary tubular biomarkers when compared to healthy young adults.
Design/Methods: In a pilot case control study, 30 patients from 18 to 35 years of age with congenital heart disease and a normal serum creatinine were recruited during a routine follow-up visit. In the same age group, 30 control subjects without history of heart or kidney disease were recruited. Urine samples were obtained to measure beta 2-microglobin, alpha 1-microglobin, N-acetyl-B-D-glucosaminidase, liver fatty acid binding protein, kidney injury molecule-1, insulin-like growth factor binding protein 7, and tissue inhibitor of metalloproteinases-2. Comparisons were done using Wilcoxon rank-sum or Fisher’s exact test.
Results: No study participants had proteinuria on urine dipstick. Median concentrations of kidney injury molecule-1 were higher (P=.01) and concentrations of insulin-like growth factor binding protein 7 (P = .001) and tissue inhibitor of metalloproteinases-2 (P = .009) were lower in the subjects with congenital heart disease when compared to the control subjects. There were no significant differences between the groups with respect to the other biomarkers.
Conclusion: Our data suggest that young adults with congenital heart disease may have subclinical kidney dysfunction. Lower levels of insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2 may indicate an impaired ability to respond to injury, while higher levels of kidney injury molecule-1 may reflect early tubular injury.

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