Open Access

ARTICLE

What is a hemodynamically significant PDA in preterm infants?

Jennifer L. Shepherd, Shahab Noori

Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California

* Corresponding Author: Shahab Noori, MD, MS CBTI, Division of Neonatology, Division of Neonatology, Children's Hospital Los Angeles, Children’s Hospital Los Angeles, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA 90027. Email:

Congenital Heart Disease 2019, 14(1), 21-26. https://doi.org/10.1111/chd.12727

Abstract

Objective: There is no consensus on the definition of a hemodynamically significant patent ductus arteriosus (hsPDA). In this review article, our objective is to discuss the main variables that one should consider when determining the hemodynamic signifi‐ cance of a PDA.
Results: We describe the various approaches that have been utilized over time to define an hsPDA and discuss the strengths and weaknesses of each echocardio‐ graphic index. Finally, we propose a comprehensive and individualized approach in determining the hemodynamic significance of the PDA.
Conclusion: There are several PDA‐related clinical, echocardiographic, and other ob‐ jective variables to take into consideration when defining an hsPDA. However, vul‐ nerability based on gestational or chronological age is an important contributor as well.

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