Guest Editors
Dr. Richard Monaghan
Email: richard.monaghan@manchester.ac.uk
Affiliation: The British Heart Foundation Centre of Research Excellence Manchester, Division of Cardiovascular Sciences, University of Manchester, UK
Homepage:
Research Interests: Molecular and Cellular Biology, Genetics, Epigenetics, Cardiovascular System Disorders, Human Epidemiology, Model Systems of Human Conditions
Dr. Simon Williams
Email: simon.williams2@manchester.ac.uk
Affiliation: The University of Manchester
Homepage:
Research Interests: Bioinformatics, Cardiovascular disease, Statistics
Dr. Yingjuan Liu
Email: yingjuan.liu@manchester.ac.uk
Affiliation: The University of Manchester
Homepage:
Research Interests: hESC biology, organoids, molecular and cell biology expert
Summary
Focusing on the great strides that have made in recent years using multiomics technology to analyse the genetic, epigenetic, transcriptomic, proteomic, metabolomic, and gross changes in subcellular morphology that occur in early heart development and their interplay with cell fate specification from the first and second heart fields, and primordial streak, we should be striving to map out in detail in the mouse the precise cohort of changes that need to be exquisitely timed for normal cardiac development so that we can define the specific requirements for this process and therefore what goes wrong during cases of congenital heart disease.
This would include articles/reviews about technologies to analyse at the single cell level all the parameters above in the developing mouse heart, in the different cardiac tissues, to map out the gene, protein, localisation of proteins, and changes in cell morphology that occur as the heart develops. The second aspect of the special issue would be articles or meta-analyses looking at CHD prevalence and mortality across ethnicities, age, socioeconomic status, countries, etc. And how along with the detailed mechanistic experiments that are the first section would only benefit specific sets of individuals unless positive changes are made to make more funding available for research into unrepresentative groups.
Commentaries regarding large-scale whole exome and genome experiments would also be covered and how these could be improved globally.
Keywords
Early embryonic heart development, Multiomics, Single cell technology, Disparities in CHD research, A roadmap of cardiac cell fate specification in the mouse
Login
Register
Submit a Paper
Propose a Special lssue