White Matter Lesions in Young-Middle Aged Migraineurs with Patent Foreman Ovale: A Case-Control Study
Yang Hua#, Jinyu Sun#, Yuxuan Lou, Hao Zhang, Jing Shi*, Wei Sun*
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, China
*
Corresponding Authors: Jing Shi. Email: shijing5499@jsph.org.cn; Wei Sun. Email: weisun7919@njmu.edu.cn
#
The first two authors contributed equally to our study
Congenital Heart Disease https://doi.org/10.32604/chd.2024.051190
Received 29 February 2024; Accepted 29 April 2024; Published online 11 June 2024
Abstract
Background: White matter lesion (WML) is common in aging brain and is associated with cognitive impairment
and dementia. However, recent studies reported an association between patent foramen ovale (PFO) and WML in
migraineurs, especially in young, middle-aged migraineurs. Our retrospective, case-control study aims to describe
the clinical characteristics of WML in this population and to explore potential risk factors.
Methods: 226 patients
with migraine and PFO were consecutively initially screened. Relevant factors were selected by the least absolute
shrinkage and selection operator (LASSO) regression and multivariable logistic regression model. A Nomogram
was employed to visualize the prediction model conveniently. The discrimination and calibration abilities were
evaluated using the Receiver Operating Characteristic (ROC) curve, the Hosmer-Lemeshow test, and calibration
curves.
Results: One hundred and nineteen participants were ultimately enrolled in our study, with a median age
of 36.9 ± 12.7 years and 80.7% of females. Brain magnetic resonance imaging MRI showed 67 (56.3%) patients
had WML, whereas 52 (43.7%) patients were categorized into the non-WML group. LASSO regression screened
out potential variables and subsequent multivariate analysis finally identified age, mean platelet volume, and fibrinogen (FIB) as independent predictive factors of WML. The area under the ROC curve (AUC) was 0.807. Hosmer-Lemeshow test and calibration curve verified a consistency between the predicted and actual probability.
Conclusion: The predictive nomogram established and validated in our study may assist clinicians in screening
WML among young middle-aged migraineurs with PFO and developing individualized preventive and treatment
strategies.
Keywords
White matter lesion; migraine; patent foreman ovale; nomogram; predictive model