Open Access

REVIEW

Mitochondrial Oxidative Stress-Associated Mechanisms in the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease

Juan Yang^1,2,#, Jiahui Zhang^3,#, Le Zhang^1,2,*, Zhenshan Yang^4,*

1 Department of Neonatology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi Children’s Hospital, Wuxi, 214000, China
2 Department of Neonatology, Affiliated Children’s Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, 214023, China
3 Department of Pediatric Laboratory, Affiliated Children’s Hospital of Jiangnan University, Wuxi Children’s Hospital, Wuxi, 214023, China
4 Division of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, 22381, Sweden

* Corresponding Authors: Le Zhang. Email: ; Zhenshan Yang. Email:
# These authors contributed equally to this work

(This article belongs to the Special Issue: Mitochondrial Dynamics and Oxidative Stress in Disease: Cellular Mechanisms and Therapeutic Targets)

BIOCELL 2025, 49(3), 399-417. https://doi.org/10.32604/biocell.2025.059908

Received 19 October 2024; Accepted 02 January 2025; Issue published 31 March 2025

Abstract

With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to focus on the recent advances in understanding mitochondrial oxidative stress-related mechanisms in the progression of MASLD. The in-depth elaboration of its related mechanisms is hoped to help find effective methods for treating MASLD.

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Keywords

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