Open Access

COMMENTARY

Qian Yang, Alina Leonie Ruff, Lydia Meder^*
BIOCELL, Vol.49, No.2, pp. 161-165, 2025, DOI:10.32604/biocell.2025.060227 - 28 February 2025
（This article belongs to the Special Issue: Genetic Biomarkers of Cancer: Insights into Molecular and Cellular Mechanisms)
Abstract This article has no abstract. More >

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240

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REVIEW

Long Qi¹, Chaoran Wu¹, Hao Sun^1,2,*, Hong Liao^1,*
BIOCELL, Vol.49, No.2, pp. 167-180, 2025, DOI:10.32604/biocell.2025.059159 - 28 February 2025
（This article belongs to the Special Issue: Cell Death and Inflammation in Signaling and Diseases)
Abstract Glutamate is an essential excitatory neurotransmitter in the brain, playing a vital role in regulating synaptic activity and maintaining the homeostasis of the cerebral environment but also serves as a central hub for neuronal injury and inflammatory responses. In various pathological conditions, such as ischemic stroke, glutamate is released and accumulates excessively in the brain, leading to heightened stimulation of neurons and excitotoxicity. This phenomenon positions glutamate as a primary inducing factor for neuronal damage following cerebral ischemia. Glutamate exerts its effects primarily through two types of receptors: ionotropic and metabotropic glutamate receptors, both of… More >

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311

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REVIEW

Sha Chen^1,#, Minkai Cao^1,#, Kerong Liu^2,*, Ying Gu^1,*
BIOCELL, Vol.49, No.2, pp. 181-198, 2025, DOI:10.32604/biocell.2025.058745 - 28 February 2025
Abstract The increasing prevalence of gestational diabetes mellitus (GDM) is associated with an array of pregnancy complications and enduring health challenges in both mothers and their offspring. Studies have indicated that exposure to the intrauterine environment can prompt adaptations in the offspring, thereby programming transgenerational inheritance. Physical activity during pregnancy, as a non-pharmacological intervention, mitigates metabolic risks through epigenetic modifications, mediating placental adaptations, the action of exercise factors, and gut microbiota. Here, we provide a review summarizing how regular exercise can reduce the risk of GDM and positively influence pregnancy outcomes. It also discusses the exercise-induced More >

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339

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REVIEW

Francesco Triggiano^#, Giusy Diella^#, Mara Lorusso, Paolo Veneziani^*, Marilena D’Ambrosio, Daniela Nesta, Luigi Santacroce^*
BIOCELL, Vol.49, No.2, pp. 199-220, 2025, DOI:10.32604/biocell.2025.059322 - 28 February 2025
Abstract The composition of the vaginal microbiota (VMB) influences the health of the female reproductive tract. Several studies have shown how the absence of lactobacilli causes an imbalance in the vaginal microbial community, favoring the development of infections. The present study aims to evaluate the relationship between the VMB and human papillomavirus (HPV) infection to clarify the role of the vaginal microbiota in the persistence and clearance of HPV. Many researchers have provided the scientific community with information on the composition of the microbiota and how it may also influence HPV infection and the development of… More >

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295

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REVIEW

Sahel Abyar^1,2, Shahrzad Shoraka², Seyed Masoud Hosseini², Mohammad Reza Zali³, Seyed Reza Mohebbi^3,*
BIOCELL, Vol.49, No.2, pp. 221-251, 2025, DOI:10.32604/biocell.2025.059787 - 28 February 2025
（This article belongs to the Special Issue: Exploring Mitochondria: Unraveling Structure, Function, and Implications in Health and Disease)
Abstract Oncogenic viruses include both DNA and RNA viruses which contribute to cancer development by disrupting cellular regulation and interfering in the immune responses. These viruses do not directly cause cancer but instead integrate their genetic material into the host genome thus, affecting cell cycle and tumor suppression. This deregulation also leads to impaired immune function and promotes tumor progression by disrupting the removal of infected cells. Generally, innate immunity consists of two important members, including mitochondria and cell deaths, which impact each other as well. Due to the close correlation between viruses, cell death pathways… More >

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ARTICLE

Lingling Zhang^1,2, Hualing Wang³, Yawen Liu², Ling Li^2,*, Jianping Xiong^1,4,*
BIOCELL, Vol.49, No.2, pp. 253-267, 2025, DOI:10.32604/biocell.2025.061585 - 28 February 2025
（This article belongs to the Special Issue: Genetic Biomarkers of Cancer: Insights into Molecular and Cellular Mechanisms)
Abstract Objective: Anillin (ANLN) is considered an oncogene in various cancers, but its effect on cervical cancer remains poorly understood. Hence, this study aimed to describe the action of ANLN on cervical cancer development and investigate the potential mechanism. Methods: Analysis of ANLN expression and its association with survival in carcinoma and endocervical adenocarcinoma (CESC) patients based on GEO and UALCAN databases. The tumor and adjacent normal tissues of 100 cervical cancer cases were harvested to detect the ANLN expression and explore its relationship with patient survival. Cell proliferation, apoptosis, migration, and invasion were measured by… More >

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268

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ARTICLE

Chang-Eui Hong¹, Su-Yun Lyu^2,*
BIOCELL, Vol.49, No.2, pp. 269-288, 2025, DOI:10.32604/biocell.2025.060411 - 28 February 2025
（This article belongs to the Special Issue: Molecular Mechanisms of Natural Compounds in Cell Signaling and Cancer Therapy)
Abstract Objectives: Despite progress in therapeutic interventions, squamous cell carcinoma of the oral cavity (OSCC) continues to pose a substantial burden on public health, with persistently poor patient outcomes. This investigation examines the growth-inhibitory and mechanistic effects of a plant-derived protein, Viscum album var. coloratum agglutinin (VCA), extracted from Korean mistletoe, against YD38 OSCC cells. Methods: The experimental protocols involved treating YD38 cells derived from human OSCC with escalating doses of VCA. Cell survival rates were quantified through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric analysis. Changes in apoptotic indices and cell cycle distribution were evaluated using flow cytometric techniques. Protein… More >

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256

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ARTICLE

Chang-Eui Hong¹, Su-Yun Lyu^2,*
BIOCELL, Vol.49, No.2, pp. 289-314, 2025, DOI:10.32604/biocell.2025.061334 - 28 February 2025
（This article belongs to the Special Issue: Innovative Approaches in Cancer and Immunology: Advances in 2D and 3D Cell Models)
Abstract Objectives: Among cutaneous malignancies, melanoma stands out for its particularly aggressive nature, with therapeutic interventions becoming notably limited once the disease progresses. In this research, we investigate the tumor-suppressing capabilities of water-extracted Korean mistletoe (Viscum album var. coloratum) and its purified lectin component (V. album var. coloratum agglutinin, VCA) using two distinct mouse melanoma models: B16BL6 and B16F10 cell lines. Methods: The impact of water extract and VCA treatments on melanoma cells was assessed through multiple experimental approaches, examining cellular survival rates, programmed cell death pathways, multicaspase activity, and cell cycle distribution patterns. To elucidate the interconnections among… More >

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192

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ARTICLE

Kuo-Yang Huang¹, Sheng-Chien Lin^2,3, Chun-Hung Su^4,5,6, Sheng-Wen Wu^4,7, Ching-Chi Tseng^8,9, Wei-Chin Hung¹⁰, Shih-Pin Chen^4,5, Yu-Hsiang Kuan^2,3,*
BIOCELL, Vol.49, No.2, pp. 315-334, 2025, DOI:10.32604/biocell.2025.061073 - 28 February 2025
（This article belongs to the Special Issue: Cellular and Molecular Mechanisms Underlying Inflammation and Immune Regulation: From Genotoxicity to Apoptosis)
Abstract Background: Acute respiratory distress syndrome (ARDS) is the major therapeutic dilemma associated with significant inflammation and severe pulmonary dysfunction. Liriodendrin is a bioactive compound extract from traditional Chinese medicine, historically utilized for modulating inflammatory responses and alleviating symptoms in multiple disease models. Methods: At present, BALB/c mice to explore the effects of liriodendrin on lipopolysaccharide (LPS)-induced ARDS. Before LPS was administered, the mice were treated with either liriodendrin or dexamethasone. Leukocyte infiltration, lung edema, and alveolar-capillary barrier integrity were evaluated in the bronchoalveolar lavage fluid (BALF) and pulmonary parenchyma. The expression of adhesion molecules and… More >

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183

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ARTICLE

Juan Cheng^1,#, Zhiwei Zhao^2,#, Ling Wang¹, Jirui Wen¹, Yali Miao^3,*, Jiang Wu^1,*
BIOCELL, Vol.49, No.2, pp. 335-348, 2025, DOI:10.32604/biocell.2025.059573 - 28 February 2025
Abstract Objectives: Recently, pre-/post-operative Local Estrogen Therapy (LET) has shown effectiveness in alleviating Pelvic Organ Prolapse (POP) symptoms in clinical therapy. However, there is a lack of scientific evidence to support these claims. Therefore, we aimed to explore the anti-senescence effects and mechanisms of 17β-estradiol (E2) on POP-derived fibroblasts. Methods: The primary fibroblast cells were isolated and cultured from the surgical samples of postmenopausal women clinically diagnosed with pelvic organ prolapse (POP) at stages III-IV (quantified using the POP-Q system) and without any other treatment within 6 months. (n = 12, age 50–75). Colorimetric Cell Counting… More >

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