Home / Journals / BIOCELL / Vol.49, No.1, 2025
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  • Open AccessOpen Access

    COMMENTARY

    Biological processes involved in mechanical force transmission in connective tissue: Linking bridges for new therapeutic applications in the rehabilitative field

    AUGUSTO FUSCO1, STEFANO BONOMI2,*, LUCA PADUA1,2
    BIOCELL, Vol.49, No.1, pp. 1-5, 2025, DOI:10.32604/biocell.2024.058418 - 24 January 2025
    Abstract Connective tissue is a dynamic structure that reacts to environmental cues to maintain homeostasis, including mechanical properties. Mechanical load influences extracellular matrix (ECM)—cell interactions and modulates cellular behavior. Mechano-regulation processes involve matrix modification and cell activation to preserve tissue function. The ECM remodeling is crucial for force transmission. Cytoskeleton components are involved in force sensing and transmission, affecting cellular adhesion, motility, and gene expression. Proper mechanical loading helps to maintain tissue health, while imbalances may lead to pathological processes. Active and passive movement, including manual mobilization, improves connective tissue elasticity, promotes ECM-cell homeostasis, and More >

    Graphic Abstract

    Biological processes involved in mechanical force transmission in connective tissue: Linking bridges for new therapeutic applications in the rehabilitative field

  • Open AccessOpen Access

    ARTICLE

    Protective Effects of Probiotics against Methotrexate-Induced Intestinal Toxicity in the Mice Model

    KSENIA S. STAFEEVA1, NATALIA A. SAMOYLOVA1, OLGA A. KARANDEEVA1, VERONIKA V. NESTEROVA1, KIRILL A. STARODUBTSEV1, EVGENY V. MIKHAILOV2, ILYA O. KRUTOV2, EVGENY S. POPOV3, NATALIA S. RODIONOVA4, ANASTASIA V. KOKINA1,5, ARTEM P. GUREEV1,5,*
    BIOCELL, Vol.49, No.1, pp. 7-20, 2025, DOI:10.32604/biocell.2024.058339 - 24 January 2025
    (This article belongs to the Special Issue: Mitochondrial Dysfunction in Metabolic and Neuromuscular Diseases: Mechanisms and Therapeutic Strategies)
    Abstract Objective: The objective of this study was to determine the level of methotrexate (MTX) toxicity in the intestines of mice and to evaluate the protective effect of probiotics composed of Streptococcus, Bifidobacterium, and Lactobacillus species on intestinal cells during MTX treatment. Methods: Mice were divided into three groups: control, MTX group (received MTX injections), and MTX + probiotics group (received MTX injections along with a diet containing probiotics). Morphological and histological changes, the level of mitochondrial DNA (mtDNA) damage, the level of lipid peroxidation products, and gene expression in the mice’s small intestine were assessed. Results: We… More >

    Graphic Abstract

    Protective Effects of Probiotics against Methotrexate-Induced Intestinal Toxicity in the Mice Model

  • Open AccessOpen Access

    REVIEW

    Advances in CRISPR-based gene editing technology and its application in nucleic acid detection

    LIUJIE CHEN1,#, LILI DUAN1,2,#, JIA LI1,2, JUN CHEN1,2, DUANFANG LIAO3, NONGYUE HE4, KAI LI1,3, ZHENG HU1,2,*
    BIOCELL, Vol.49, No.1, pp. 21-43, 2025, DOI:10.32604/biocell.2024.056698 - 24 January 2025
    Abstract Nucleic acid analysis is a key technique that enables accurate detection of various microorganisms. Conventional nucleic acid testing typically requires access to specialized laboratories, equipment, and trained personnel, which hinders the widespread use of on-site testing for DNA and RNA targets. However, integrating gene editing technology with traditional nucleic acid detection methods, especially isothermal amplification technology, can help overcome the limitations associated with on-site testing. This combination can accomplish precise and swift detection of nucleic acid sequences, offering a robust tool for on-site detection. The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated proteins (CRISPR/Cas) technology, which More >

  • Open AccessOpen Access

    REVIEW

    Development and application prospect of stem cell combined with 3D printing technology for oral disease

    YIXIAN YOU1,3,#, YIHUNG LEE2,#, YUSHIN HU2, YOUHUI XU3, JOUCHEN CHEN2, WEI JIANG1, CHANGHAI LIU1, ENQIANG CHEN1, HONG TANG1, HUA ZHANG4,*, DONGBO WU1,*
    BIOCELL, Vol.49, No.1, pp. 45-59, 2025, DOI:10.32604/biocell.2024.057259 - 24 January 2025
    Abstract With organ transplantation facing many dilemmas, tissue and organ regeneration as an alternative has bright prospects. In regenerative medicine, Three-dimensional (3D) printing technology and stem cells has been widely applied to the treatment of diseases related to tissue or organ replacement in dentistry, respectively. However, there are very few studies on the combination of the two, and even fewer clinical studies have been reported in dentistry. In this review, the current oral tissue engineering in vivo and in vitro based on 3D printing and stem cell technology will be summarized, and the discussion on the development… More >

  • Open AccessOpen Access

    REVIEW

    Macrophage polarization in cardiac transplantation: Insights into immune modulation and therapeutic approaches

    JINGWEI JIANG1,2, BO JIA3, CHUAN WANG3, CHEN FANG1, YUGUI LI1, GUOXING LING1, BAOSHI ZHENG1,*, CHENG LUO1,*
    BIOCELL, Vol.49, No.1, pp. 61-78, 2025, DOI:10.32604/biocell.2024.056981 - 24 January 2025
    (This article belongs to the Special Issue: Exploring Mitochondria: Unraveling Structure, Function, and Implications in Health and Disease)
    Abstract The role and regulatory mechanisms of macrophage polarization in cardiac transplantation have gained significant attention. Macrophages can polarize into either the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype in response to environmental cues. M1 macrophages facilitate transplant rejection by releasing inflammatory mediators and activating T cells, whereas M2 macrophages support graft survival by secreting anti-inflammatory factors and promoting tissue repair. Mitochondrial quality control regulation plays a crucial role in macrophage polarization, which may influence graft survival and immune responses. This review provides an overview of the current understanding of mitochondrial quality control-regulated macrophage polarization in cardiac More >

  • Open AccessOpen Access

    REVIEW

    Exploring the mechanistic role of epidermal growth factor receptor activation in non-cancer kidney disease

    JU-YEON LEE1, DAEUN MOON2, JINU KIM2,3,*
    BIOCELL, Vol.49, No.1, pp. 79-92, 2025, DOI:10.32604/biocell.2024.058340 - 24 January 2025
    Abstract The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses. This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases. EGFR signaling is essential for kidney function and repair mechanisms, and its dysregulation significantly impacts both acute and chronic kidney conditions. The review discusses the normal distribution of EGFR in kidney tubular segments, the mechanism of its activation and inhibition, and the therapeutic potential of EGFR-targeting antagonists and ligands. Additionally, it explores the pathophysiological characteristics observed More >

  • Open AccessOpen Access

    REVIEW

    How does Hedgehog signaling participate in the cross-interaction of hormones and testis development?

    JUN-JIE YU, WAN-XI YANG*
    BIOCELL, Vol.49, No.1, pp. 93-107, 2025, DOI:10.32604/biocell.2024.058299 - 24 January 2025
    Abstract Hedgehog (HH) signaling has been researched for decades and Hedgehog has 3 homologs: Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh). Dhh is the one involved in male gonad and germ cell development. The distribution of molecules in Hedgehog signaling in testis indicated that Hedgehog signaling executes important functions during testis development. The patients with Dhh signaling deficiency develop dysgenesis of gonads and hormone production which demands further exploration of gonad HH signaling. Some results proved the indispensable roles of HH signaling in gonad and germ cell development and the interaction with More >

    Graphic Abstract

    How does Hedgehog signaling participate in the cross-interaction of hormones and testis development?

  • Open AccessOpen Access

    REVIEW

    Therapeutic actions of terpenes in neurodegenerative disorders and their correlations with the regulation and remodeling of the extracellular matrix

    RENATA DA SILVA CARNEIRO1, MATEUS HENRIQUE DE ALMEIDA DA COSTA1, JOSé ZILTON LIMA VERDE SANTOS1, VALDILéIA TEIXEIRA UCHôA2, LUCIANO DA SILVA LOPES3, ANDERSON NOGUEIRA MENDES1,*
    BIOCELL, Vol.49, No.1, pp. 109-125, 2025, DOI:10.32604/biocell.2024.058405 - 24 January 2025
    (This article belongs to the Special Issue: Extracellular Matrix in Development and Disease)
    Abstract Neurodegenerative diseases are a major public health challenge, mainly affecting the elderly population and compromising their cognitive, sensory, and motor functions. Currently, available therapies focus on alleviating symptoms and slowing the progression of these conditions, but they do not yet offer a definitive cure. In this scenario, terpenes emerge as promising natural alternatives due to their neuroprotective properties. These compounds can reduce the formation of protein aggregates, neutralize free radicals, and inhibit pro-inflammatory enzymes, which are crucial factors in the development of neurodegenerative diseases. In addition, terpenes also play an important role in the… More >

  • Open AccessOpen Access

    REVIEW

    E3 Ligases and COVID-19: Insights into Viral Control and Therapeutic Potential

    Mukul Mishra1, Deeba Khan2, Sehbanul Islam1,*
    BIOCELL, Vol.49, No.1, pp. 127-147, 2025, DOI:10.32604/biocell.2025.058038 - 24 January 2025
    (This article belongs to the Special Issue: Functional Interactions Between Viral Proteins and Cellular Mechanisms)
    Abstract The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their More >

  • Open AccessOpen Access

    REVIEW

    The genetics of pediatric inflammatory bowel disease: Towards precision medicine

    AHMAD SHAHIR MOHAMAD NAZRI, NAZIHAH MOHD YUNUS, MARAHAINI MUSA*
    BIOCELL, Vol.49, No.1, pp. 149-160, 2025, DOI:10.32604/biocell.2024.057352 - 24 January 2025
    Abstract Pediatric inflammatory bowel disease (IBD) is a chronic and heterogeneous disease. IBD is commonly classified into Crohn’s disease and ulcerative colitis. It is linked to serious symptoms and complications. The onset of IBD commonly occurs during adolescence. Despite the significant number of cases globally (~5 million), the causes of pediatric IBD, which constitutes 25% of IBD patients, are not yet fully understood. Apart from environmental factors, genetic factors contribute to a higher risk of developing IBD. The predisposition risk of IBD can be investigated using genetic testing. Genetic mechanisms of pediatric IBD are highly complex More >

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