Open Access

REVIEW

Three-dimensional cell-based strategies for liver regeneration

by DAN GUO¹, XI XIA^2,*, JIAN YANG^1,*

1 Liver Transplant Center, Transplant Center, West China Hospital, Sichuan University, Chengdu, 610041, China
2 Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, 610212, China

* Corresponding Authors: XI XIA. Email: ; JIAN YANG. Email:

(This article belongs to the Special Issue: Perspectives on Stem Cells and Regenerative Medicine)

BIOCELL 2024, 48(7), 1023-1036. https://doi.org/10.32604/biocell.2024.051095

Received 27 February 2024; Accepted 28 March 2024; Issue published 03 July 2024

Abstract

Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine. In recent years, the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical requirements. This review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver failure. Here, we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver failure. Furthermore, we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical applications. The collective insights presented herein highlight the significance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.

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Keywords

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