Open Access

REVIEW

Research progress on natural products against hepatocellular carcinoma

LINGLI ZHANG^1,2,#, YAN LI^1,#, JINGXIN MAO^1,*

1 Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Medical and Pharmaceutical College, Chongqing, 400030, China
2 Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Life Sciences and Biopharmaceuticals, Guangdong Pharmaceutical University, Guangzhou, 510006, China

* Corresponding Author: JINGXIN MAO. Email:

BIOCELL 2024, 48(6), 905-922. https://doi.org/10.32604/biocell.2024.050396

Received 05 February 2024; Accepted 24 April 2024; Issue published 10 June 2024

Abstract

Hepatocellular carcinoma (HCC) remains a prevalent and challenging malignancy globally, characterized by its numerous causal factors and generally unfavorable prognosis. In the relentless pursuit of effective treatment modalities, natural products have emerged as a promising and relatively non-toxic alternative, garnering significant interest. The integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of HCC. This review offers a comprehensive overview of the causal factors underlying HCC, and the diverse treatment options available, and highlights the advancements made by natural products in anti-HCC research. Particularly, we provide an outline of the various types of natural products, their corresponding nomenclature, target molecules, and mechanisms of action that exhibit anti-HCC activities. Natural products are anticipated to play a pivotal role in future comprehensive treatment plans for liver cancer, potentially offering patients improved survival rates and an enhanced quality of life.

---

Keywords

---