Open Access

REVIEW

Mesenchymal stem cells and the angiogenic regulatory network with potential incorporation and modification for therapeutic development

VAN THI TUONG NGUYEN^1,2, KHUONG DUY PHAM^1,2,3, HUONG THI QUE CAO^1,2, PHUC VAN PHAM^1,2,*

1 Stem Cell Institute, University of Science Ho Chi Minh City, Ho Chi Minh City, Viet Nam
2 Viet Nam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam
3 Laboratory of Stem Cell Research and Application, University of Science Ho Chi Minh City, Ho Chi Minh City, Viet Nam

* Corresponding Author: PHUC VAN PHAM. Email:

(This article belongs to the Special Issue: Perspectives on Stem Cells and Regenerative Medicine)

BIOCELL 2024, 48(2), 173-189. https://doi.org/10.32604/biocell.2023.043664

Received 14 July 2023; Accepted 23 October 2023; Issue published 23 February 2024

Abstract

Mesenchymal stem cells (MSCs) have been proposed in regenerative medicine, especially for angiogenic purposes, due to their potential to self-renew, differentiate, and regulate the microenvironment. Peripheral vascular diseases, which are associated with reduced blood supply, have been treated but not cured. An effective therapy is to recover blood supply via vessel regeneration in the affected area, and MSCs appear to be promising for such conditions. Several studies aimed to explore the role of MSCs in performing angiogenesis and have revealed numerous potential methods to enhance MSC capacity in vessel formation. Efforts have been made to modify standard MSCs to optimize their prospective characteristics. Thus, understanding the mechanism underlying MSC angiogenic potential, and learning how to control their effect in the in vivo environment is critical for success in clinical settings. This review covers the angiogenesis process and discusses the role of some of the key angiogenic regulators. Possible techniques to enhance the angiogenic capacity of MSCs are also mentioned to suggest potential methods for therapeutic application.

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