Open Access

REVIEW

Review on marine collagen peptides induce cancer cell apoptosis, necrosis, and autophagy by reducing oxidized free radicals

YINGHUA LUO^1,#, YU ZHANG^2,#, TONG ZHANG^2,#, YANNAN LI², HUI XUE², JINGLONG CAO², WENSHUANG HOU², JIAN LIU², YUHE CUI², TING XU², CHENGHAO JIN^2,3,*

1 Department of Grass Science, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China
2 Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, China
3 National Coarse Cereals Engineering Research Center, Daqing, 163319, China

* Corresponding Author: CHENGHAO JIN. Email:
# These authors contributed equally to this work as the first author

BIOCELL 2023, 47(5), 965-975. https://doi.org/10.32604/biocell.2023.027729

Received 12 November 2022; Accepted 31 January 2023; Issue published 10 April 2023

Abstract

Marine collagen peptides (MCPs) are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or enzymes. MCPs have a range of structures and biological activities and are widely present in marine species. MCPs also have a small molecular weight, are easily modified, and absorbed by the body. These properties have attracted great interest from researchers studying antioxidant, anti-tumor, and anti-aging activities. MCPs of specific molecular weights have significant anti-tumor activity and no toxic side effects. Thus, MCPs have the potential use as anti-cancer adjuvant drugs. Free radicals produced by oxidation are closely related to human aging, cancer, arteriosclerosis, and other diseases, but their relationship with cancer is not well known. In this review, we focus on the antioxidant properties of MCPs in the treatment of cancer, highlighting their antioxidant molecular structure and potential for clinical practice.

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