Open Access

REVIEW

Fe-dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?

by PAULA MARIELA GONZÁLEZ^1,2, JOAQUIN CABRERA^1,2, SUSANA PUNTARULO^1,2,*

1 Fisicoquímica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, C1113 AAD, Argentina
2 Instituto de Bioquímica y Medicina Molecular (IBIMOL), CONICET-Universidad de Buenos Aires, Buenos Aires, C1113 AAD, Argentina

* Corresponding Author: SUSANA PUNTARULO. Email:

BIOCELL 2023, 47(5), 1177-1189. https://doi.org/10.32604/biocell.2023.027107

Received 18 October 2022; Accepted 26 December 2022; Issue published 10 April 2023

Abstract

The purpose of this review is to briefly summarize the central role of iron (Fe) in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic organisms. In ferroptotic cells or tissues, the intracellular Fe level increases; meanwhile the treatment with Fe chelators limits ferroptosis. Eukaryotic algae can assimilate Fe from the environment through several mechanisms, and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic matter. The central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell death. Aquatic animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to ferroptosis. The ferroptosis reaction can be regulated through the antioxidant defense system, in combination with the protein degradation structure, metabolism, and gene transcription. Early depletion of non-enzymatic antioxidants like reduced glutathione (GSH) in animals, and the reduction of both GSH and ascorbate in photosynthetic organisms, are characteristic features of ferroptosis. Therefore, ferroptosis can be prevented if Fe chelators, certain antioxidants, and specifically regulating genes are activated. Thus, the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously understood. Much more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.

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Keywords

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