Open Access

REVIEW

Research progress of TRIMs protein family in tumors

YUANYUAN HUANG^#, HONGMEI WU^#, RUYUAN LIU, SONG JIN, WEILAI XIANG, CHANG YANG, LI XU, XIAONIAN ZHU^*

Department of Health Toxicology, School of Public Health, Guilin Medical University, Guilin, 541199, China

* Corresponding Author: XIAONIAN ZHU. Email:

(This article belongs to the Special Issue: Recent Advancement in Cancer Molecular Signaling)

BIOCELL 2023, 47(3), 445-454. https://doi.org/10.32604/biocell.2023.025880

Received 04 August 2022; Accepted 15 November 2022; Issue published 03 January 2023

Abstract

The tripartite motif (TRIMs) protein family has E3 ubiquitin ligase activity among most of its members. They participate in multiple cellular processes and signaling pathways in living organisms, including cell cycle, growth, and metabolism, and mediate chromatin modification, transcriptional regulation, post-translational modification, and cellular autophagy. Previous studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor patients. Here we summarize the biological roles of the TRIMs protein family in cancers.

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