Open Access

VIEWPOINT

Inflammatory priming of mesenchymal stem cells: Focus on growth factors enhancement

ALEKSANDRA GORNOSTAEVA, ELENA ANDREEVA^*, LUDMILA BURAVKOVA^*

Cell Physiology Laboratory, Institute of Biomedical Problems of Russian Academy of Sciences, Moscow, 123007, Russia

* Corresponding Authors: Elena Andreeva, ; Ludmila Buravkova,

(This article belongs to the Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)

BIOCELL 2022, 46(9), 2049-2052. https://doi.org/10.32604/biocell.2022.019993

Received 28 October 2021; Accepted 17 January 2022; Issue published 18 May 2022

Abstract

Multipotent mesenchymal stromal cells (MSCs) are actively involved in reparation and inflammation processes, providing damaged tissue reparation and suppressing immune cell responses in vivo. The effects are mostly due to the production of a wide range of paracrine factors, including growth factors and immunomodulatory mediators. To induce immunosuppressive activity, MSCs are primed by inflammatory cytokines, which results in an increased production of immunomodulatory molecules. However, stimulation of reparative properties is also necessary. This viewpoint manuscript highlights the possibilities of inflammatory priming to increase the production of growth factors by MSCs.

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