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Cardiac stromal cells on stage: From dull filler to specialized actors

by VITTORIO PICCHIO¹, FRANCESCA PAGANO², ISOTTA CHIMENTI^1,3,*

1 Department of Medical Surgical Sciences and Biotechnologies, Sapienza University, Latina, 04100, Italy
2 Institute of Biochemistry and Cell Biology, National Council of Research (IBBC-CNR), Monterotondo, 00015, Italy
3 Mediterranea Cardiocentro, Napoli, 80122, Italy

* Corresponding Author: Isotta Chimenti,

BIOCELL 2022, 46(8), 1875-1877. https://doi.org/10.32604/biocell.2022.020181

Received 09 November 2021; Accepted 13 December 2021; Issue published 22 April 2022

Abstract

Cardiac stromal cells have faced through the years a significant evolution in their definitions concerning their phenotypes, markers, and functions. They are surging to key roles in physiopathology, becoming important targets to be exploited for cardiac repair. In this perspective, we briefly discuss their role in novel therapeutic strategies for enhancing cardiac repair and regeneration.

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Keywords

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