TY - EJOU
AU - RUDZIĆSKA-RADECKA, MAGDALENA
TI - A potential impact of A Disintegrin and Metalloproteinase DomainLike Protein Decysin-1 (ADAMDEC1) on clear cell renal cell carcinoma propagation
T2 - BIOCELL
PY - 2022
VL - 46
IS - 8
SN - 1667-5746
AB - Clear cell renal cell carcinoma (KIRC) is the most common and aggressive malignancy subtype of renal neoplasm
that arises from proximal convoluted tubules. It is characterized by poor clinical outcomes and high mortality of patients due
to the lack of specific biomarkers for varying stages of the disease and no effective treatment. Proteases are associated with
the development of several malignant tumors in humans by their ability to degrade extracellular matrices, facilitating
metastasis. Herein, differentially expressed genes in KIRC cases compared to healthy kidneys were screened out from the
Gene Expression Profiling Interactive Analysis (GEPIA) database. This data was applied to determine the most elevated
protease in KIRC and as a result, A Disintegrin and Metalloproteinase Domain-Like Protein Decysin-1 (ADAMDEC1)
was selected. This expression pattern was exclusive for KIRC and not observed for papillary and chromophobe renal cell
carcinomas, in which ADAMDEC1 was at the same level in tumors and non-cancer specimens. Furthermore, the
ADAMDEC1 significant increase was detected in the fourteen other human malignancies compared to healthy samples,
which suggested its strong involvement in cancer development. Next, GEPIA and Pathology Atlas correlated
ADAMDEC1 high expression with more advanced tumor grade and shorter survival of KIRC patients. Xena Functional
Genomics Explorer presented that ADAMDEC1 could be hypermethylated in some tumor cases and one somatic
mutation in the gene sequence was detected. Finally, a Search Tool for the Retrieval of Interacting Genes/Proteins;
STRING base was utilized to predict the interactions of ADAMDEC1 with other molecules and construct the signaling
network. In summary, ADAMDEC1 showed the tremendous potential to be the predictive marker for the KIRC and its
development. Therefore, this review with data analysis can be a good base for further in vitro and in vivo research that
experimentally can confirm the ADAMDEC1 as prognostic biomarkers and therapeutic target of KIRC.
KW - A Disintegrin and Metalloproteinase Domain-Like Protein Decysin-1
KW - ADAMDEC1
KW - Clear cell renal cell carcinoma
KW - Patient specimens
KW - Databases
DO - 10.32604/biocell.2022.019724