Open Access

ARTICLE

Secondary antiviral metabolites from fungi with special reference to coronaviruses

by MOHAMED SALEM^1,2, MOHAMMAD EL-METWALLY³, WESAMELDIN SABER^4,*, SALLY NEGM^5,6, ATTALLA EL-KOTT^7,8, YASSER MAZROUA^9,10, ABEER MAKHLOUF¹¹, MAHMOUD MOUSTAFA^7,12

1 Department of Chemistry, Faculty of Science and Art, King Khalid University, Mohail, Assir, Saudi Arabia
2 Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
3 Botany and Microbiology Department, Faculty of Science, Damanhour University, El-Behera, Egypt
4 Microbial Activity Unit, Department of Microbiology, Soils, Water and Environment Research Institute, Agricultural Research Center, Giza, Egypt
5 Life Sciences Department, College of Science and Art, King Khalid University, Mohail, Aseer, Saudi Arabia
6 Unit of Food Bacteriology, Central Laboratory of Food Hygiene, Ministry of Health, Sharkia, Egypt
7 Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia
8 Zoology Department, Faculty of Science, Damanhour University, El-Behera, Egypt
9 Department of Business Administration, Community College, King Khalid University, Abha, Saudi Arabia 10 Department of Agricultural Economics, Faculty of Agriculture, Tanta University, Tanta, Egypt
11 Department of Botany, Faculty of Agriculture, Menoufia University, Sheben El-Kom, Menoufia, Egypt
12 Botany and Microbiology Department, Faculty of Science, South Valley University, Qena, Egypt

* Corresponding Author: Wesameldin Saber,

BIOCELL 2022, 46(8), 1979-1988. https://doi.org/10.32604/biocell.2022.019301

Received 15 September 2021; Accepted 26 October 2021; Issue published 22 April 2022

Abstract

Profound inspection of the life forms on the earth teaches how to be the complexity of interrelationships among the various systems. Because of the emergence of novel viruses all the time and the inadequate of vaccines and antivirals, viral contagions are amongst the most causative diseases affecting people worldwide. Fungi exemplify a massive source of bioactive molecules as, many fungal secondary metabolities like Oxoglyantrypine, Carneic acid F, Scedapin C, Asteltoxin E, Phomanolide, Norquinadoline A and Quinadoline B have antiviral activity. This review deals with how secondary metabolites of fungi can help in the war against viruses in general and especially Coronaviruses moreover several pieces of literature pointed out that many clusters of fungi in different biotopes are waiting to be exploited.

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Keywords

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