Open Access

REVIEW

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR): A critical overview on the most promising applications of molecular scissors in oral medicine

by MARCO TATULLO^1,*, LUISA LIMONGELLI², ROSA MARIA MARANO³, ALESSANDRA VALLETTA⁴, ANGELA TEMPESTA², SANDRO RENGO⁴

1 Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, 74124, Italy
2 Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, 74124, Italy
3 Marrelli Health-Tecnologica Research Institute, Biomedical Section, Stem Cells and Medical Genetics Units, Crotone, 88900, Italy
4 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, 80131, Italy

* Corresponding Author: Marco Tatullo,

BIOCELL 2022, 46(8), 1837-1842. https://doi.org/10.32604/biocell.2022.020570

Received 01 December 2021; Accepted 27 January 2022; Issue published 22 April 2022

Abstract

The scientific community is continuously working to translate the novel biomedical techniques into effective medical treatments. CRISPR-Cas 9 system (Clustered Regularly Interspaced Short Palindromic Repeats-9), commonly known as the “molecular scissor”, represents a recently developed biotechnology able to improve the quality and the efficacy of traditional treatments, related to several human diseases, such as chronic diseases, neurodegenerative pathologies and, interestingly, oral diseases. Of course, dental medicine has notably increased the use of biotechnologies to ensure modern and conservative approaches: in this landscape, the use of CRISPR-Cas-9 system may speed and personalize the traditional therapies, ensuring a good predictability of clinical results. The aim of this critical overview is to provide evidence on CRISPR efficacy, taking into specific account its applications in oral medicine.

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