Open Access

ARTICLE

Long non-coding RNA MIR22HG inhibits the adipogenesis of human bone marrow mesenchymal stem cells with the involvement of Wnt/β-catenin pathway

by CHANYUAN JIN^1,4,#, ZIYAO ZHUANG^2,4,#, LINGFEI JIA^3,4,*, YUNFEI ZHENG^2,4,*

1 Second Clinical Division, Peking University School and Hospital of Stomatology, Beijing, 100081, China
2 Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China
3 Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China
4 National Center of Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, 100081, China

* Corresponding Authors: LINGFEI JIA. Email: ; YUNFEI ZHENG. Email:
# Authors contributed equally

BIOCELL 2022, 46(7), 1717-1724. https://doi.org/10.32604/biocell.2022.018706

Received 13 August 2021; Accepted 18 October 2021; Issue published 17 March 2022

Abstract

Osteoporosis is a frequently occurring bone remodeling disorder worldwide with one characteristic being decreasing bone mineral density and a predisposition to bone fracture, which diminishes patients’ quality of life. Several studies showed that imbalance between the osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) took part in the development of osteoporosis. In previous study, we found MIR22HG regulated the osteogenesis of human BMSCs positively. In this study, we found that MIR22HG was decreased during the adipogenesis of human BMSCs and exerted negative effects on adipogenesis with the involvement of Wnt/β-catenin signaling pathway both in vitro and in vivo. Nitazoxanide could inhibit Wnt signaling and relieve MIR22HG’s suppression on adipogenesis. These findings indicated that MIR22HG had great potential in clinical application for osteoporosis treatment and prevention.

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Keywords

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