TY - EJOU AU - WANG, ZIQIAN AU - LI, YAQI AU - WANG, DONGYANG AU - SHEN, YINGQIANG TI - Ferroptosis molecular inducers: A future direction for malignant tumor chemotherapy T2 - BIOCELL PY - 2022 VL - 46 IS - 7 SN - 1667-5746 AB - Iron-dependent ferroptosis is a form of cell death dependent on iron levels. Cells that undergo ferroptosis have glutathione (GSH) deficiency, reduced Glutathione peroxidase-4 (GPX4) activity and intracellular lipid peroxidation, Mitochondria, lysosomes and many signal pathways are involved in the regulation of ferroptosis. More importantly, many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis. Moreover, over recent years, a number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors. Therefore, the study of ferroptosis is of great significance for future cancer treatments. In this review, we discussed the metabolic process of ferroptosis, the role of different organelles, the typical signaling pathways involved in ferroptosis, as well as natural and synthetic compounds that can induce ferroptosis, aiming to point out new conceptual avenues for utilizing ferroptosis in future cancer treatments. KW - Ferroptosis KW - Cancer KW - Organelle KW - Pathways KW - Ferroptosis-induced drugs DO - 10.32604/biocell.2022.018530