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Co-regulator NCOA5 and cancer

YUANYUAN CHEN, SHUAISHUAI CUI, YUNFEI GUO, DAHU CHEN^*

School of Life Sciences, Shandong University of Technology, Zibo, 225000, China

* Corresponding Author: Dahu Chen,

(This article belongs to the Special Issue: Biochemical and Epigenetics Changes in Health and Disease)

BIOCELL 2022, 46(7), 1643-1650. https://doi.org/10.32604/biocell.2022.019142

Received 05 September 2021; Accepted 04 November 2021; Issue published 17 March 2022

Abstract

NCOA5 encodes a co-regulator for estrogen receptors (ERα and ERβ), orphan nuclear receptors (REV-ERBα and REV-ERBβ) and liver X receptor. It can influence many cellular processes by either promoting or inhibiting gene expression through its two important functional motifs: LxxLL (co-activator) and ΦxxΦΦ (co-repressor). Many reports have revealed the important roles of NCOA5 in diseases, such as diabetes, reproductive defects and autoimmune disease. In this review, we focus on its function in cancers and summary the current research progresses regarding its different roles in various cancers.

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