Open Access
VIEWPOINT
Microenvironment and cell mechanics
VAN-CHIEN BUI*
Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, 17475, Greifswald, Germany
* Corresponding Author: Van-Chien Bui,
BIOCELL 2022, 46(7), 1629-1632. https://doi.org/10.32604/biocell.2022.018364
Received 21 July 2021; Accepted 08 September 2021; Issue published 17 March 2022
Abstract
Microenvironment contains biophysical and biochemical elements to maintain survival, growth, proliferation,
and differentiation of cells. Any change can lead to cell response to the mechanical forces, which can be described by
elasticity. It is an indicator of a cell’s state since it plays an important role in many cellular processes. In many cases,
cell elasticity is measured by using discontinuous manner, which may not allow elucidating real-time activity of
individual live cells in physiological condition or cell response against microenvironmental changes. I argue that
measuring cell elasticity using continuously repetitive nanoindentation technique is important that should be
considered. As an example, I discuss mechanics of human embryonic kidney (HEK) cells in various conditions. In
resting cells, there is an activity of the cytoskeleton whose oscillation amplitude is strongly affected by the intracellular
calcium, and the collective activity of myosin motor proteins induces elasticity oscillation. Experimental results also
reveal that actin cytoskeleton and cell membrane determine cell mechanics.
Keywords
Cite This Article
APA Style
BUI, V. (2022). Microenvironment and cell mechanics. BIOCELL, 46(7), 1629-1632. https://doi.org/10.32604/biocell.2022.018364
Vancouver Style
BUI V. Microenvironment and cell mechanics. BIOCELL . 2022;46(7):1629-1632 https://doi.org/10.32604/biocell.2022.018364
IEEE Style
V. BUI, "Microenvironment and cell mechanics," BIOCELL , vol. 46, no. 7, pp. 1629-1632. 2022. https://doi.org/10.32604/biocell.2022.018364