Open Access
VIEWPOINT
Prognostic, diagnostic and therapeutic potential of endothelial progenitor cells for patients with ischaemic stroke: Hype or Hope
ULVI BAYRAKTUTAN*
Academic Unit of Mental Health and Clinical Neuroscience, School of Medicine, Nottingham, NG5 1PB, UK
* Corresponding Author: Ulvi Bayraktutan,
BIOCELL 2022, 46(7), 1593-1598. https://doi.org/10.32604/biocell.2022.018679
Received 10 August 2021; Accepted 23 August 2021; Issue published 17 March 2022
Abstract
Ischaemic stroke is a debilitating disease with immense personal, societal and economic impact. Thrombolysis
with recombinant tissue plasminogen activator remains the only approved pharmacotherapy for this disease. As each year
less than 1% of eligible patients receive this therapy worldwide, efficacious new therapeutics are desperately needed.
Emerging evidence suggest endothelial progenitor cells (EPCs), capable of repairing damaged vasculature, as one such
therapeutics. However, questions regarding their optimal dose, delivery route and in vivo survivability remain largely
unanswered. Outgrowth endothelial cells, generated in large numbers by ex vivo expansion of EPCs, enable effective
assessment of these issues and may eventually serve as off-the-shelf therapeutics. Correlations between circulating
EPC levels and stroke outcome imply that EPCs may also serve as clinical biomarkers for stroke. This viewpoint
briefly evaluates the current evidence, pinpoints the gaps in the literature and proposes new directions for research.
Keywords
Cite This Article
APA Style
BAYRAKTUTAN, U. (2022). Prognostic, diagnostic and therapeutic potential of endothelial progenitor cells for patients with ischaemic stroke: hype or hope. BIOCELL, 46(7), 1593-1598. https://doi.org/10.32604/biocell.2022.018679
Vancouver Style
BAYRAKTUTAN U. Prognostic, diagnostic and therapeutic potential of endothelial progenitor cells for patients with ischaemic stroke: hype or hope. BIOCELL . 2022;46(7):1593-1598 https://doi.org/10.32604/biocell.2022.018679
IEEE Style
U. BAYRAKTUTAN, "Prognostic, diagnostic and therapeutic potential of endothelial progenitor cells for patients with ischaemic stroke: Hype or Hope," BIOCELL , vol. 46, no. 7, pp. 1593-1598. 2022. https://doi.org/10.32604/biocell.2022.018679