Open Access

REVIEW

Biomedical overview of melanin. 2. Updating molecular modeling, synthesis mechanism, and supramolecular properties regarding melanoma therapy

JUAN CARLOS STOCKERT^1,2,*, ALFONSO BLÁZQUEZ-CASTRO³

1 Facultad de Medicina, Instituto de Oncología “Angel H. Roffo”, Universidad de Buenos Aires, Buenos Aires, C1417DTB, Argentina
2 Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O’Higgins, Santiago, 8370854, Chile
3 Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, 28049, Spain

* Address correspondence to: Juan Carlos Stockert,

BIOCELL 2022, 46(6), 1391-1415. https://doi.org/10.32604/biocell.2022.019493

Received 27 September 2021; Accepted 19 November 2021; Issue published 07 February 2022

Abstract

Melanins represent one of the most ancient and important group of natural macromolecular pigments. They have multiple biological roles in almost all organisms across the Phyla, examples being photoprotection, anti-oxidative action, radical scavenger activity, and heavy metal removal. From the biomedical point of view, melanocytes are involved in the origin of melanoma tumors, and the main therapeutic advances for their treatment have been revised in Part 1 of this review. The chemical structure of eumelanin is a biological concern of great importance, and therefore, exploring theoretical molecular models and synthesis mechanisms will be here described, as well as molecular orbital features and supramolecular organization, which are responsible for the key properties that make these biological pigments so important, and so fascinating. Ultimately, this updated overview is devoted to describe present structural models and physico-chemical characteristics of eumelanin, in order to explain and utilize melanin properties on which new photothermal and ultrasonic protocols for melanoma treatment can be devised and applied.

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