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Applications of scaffolds: Tools for enhancing the immunomodulation of mesenchymal stromal cells

OK-HYEON KIM1,2,#, EUN RAN KIM3,#, JUN HYUNG PARK2, HYUN JUNG LEE1,2,*

1 Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul, 06974, South Korea
2 Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, South Korea
3 Severance Biomedical Science Institute, Yonsei Biomedical Research Institute, College of Medicine, Yonsei University, Seoul, 03722, South Korea

* Address correspondence to: Hyun Jung Lee, email
# Equally contributed as first authors

(This article belongs to the Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)

BIOCELL 2022, 46(6), 1439-1443. https://doi.org/10.32604/biocell.2022.018921

Abstract

Exogenously delivered mesenchymal stromal cells (MSCs) are therapeutically beneficial owing to their paracrine effect; they secrete various cytokines, nucleic acids, and proteins. Multiple bioengineering techniques can help MSC cultures to release secretomes by providing stem cell niche-like conditions (both structurally and functionally). Various scaffolds mimic the natural extracellular matrix (ECM) using both natural and synthetic polymers, providing favorable environments for MSC proliferation and differentiation. Depending on material properties, either topographically or elastically structured scaffolds can be fabricated. Three-dimensional scaffolds have tunable substrate rigidities and structures, aiding MSC cultivation. Decellularized ECM-derived hydrogels are similar to the natural ECM, thus improving the paracrine effects of MSCs. Here, we discuss recent research on the application of scaffolds to maximize the immunomodulatory function of MSCs.

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APA Style
KIM, O., KIM, E.R., PARK, J.H., LEE, H.J. (2022). Applications of scaffolds: tools for enhancing the immunomodulation of mesenchymal stromal cells. BIOCELL, 46(6), 1439-1443. https://doi.org/10.32604/biocell.2022.018921
Vancouver Style
KIM O, KIM ER, PARK JH, LEE HJ. Applications of scaffolds: tools for enhancing the immunomodulation of mesenchymal stromal cells. BIOCELL . 2022;46(6):1439-1443 https://doi.org/10.32604/biocell.2022.018921
IEEE Style
O. KIM, E.R. KIM, J.H. PARK, and H.J. LEE, “Applications of scaffolds: Tools for enhancing the immunomodulation of mesenchymal stromal cells,” BIOCELL , vol. 46, no. 6, pp. 1439-1443, 2022. https://doi.org/10.32604/biocell.2022.018921



cc Copyright © 2022 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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