Open Access

VIEWPOINT

MSCs-exosomes in regeneration medicine: Current evidence and future perspectives

BENSHUAI YOU¹, HUI QIAN^1,2,*

1 Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China
2 NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, 200040, China

* Address correspondence to: Hui Qian,

BIOCELL 2022, 46(6), 1459-1463. https://doi.org/10.32604/biocell.2022.018378

Received 20 July 2021; Accepted 09 October 2021; Issue published 07 February 2022

Abstract

Exosomes, especially from mesenchymal stem cells, have attracted extensive attention in regeneration medicine. Mesenchymal stem cells derived exosomes (MSCs-exosomes) have shown anti-inflammatory, anti-oxidant, anti-apoptosis and tissue regeneration effects in a variety of tissue injury repair models. MSCs-exosomes hold many excellent properties such as low immunogenicity, biocompatibility, and targeting capability. With the in-depth study on the generation and function of exosomes, MSCs-exosomes are considered to be the bright stars in the field of regenerative medicine. However, there are still many obstacles to overcome in terms of exosomes isolation, clinical trials and safety evaluation. In this article, what we should focus on about MSCs-exosomes in regeneration medicine will be discussed.

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Keywords

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