Open Access

REVIEW

Use of Impella cardiac axial flow pump for cardiogenic shock (A newer alternative)–How good is the evidence?

by RAFIQ AHMED BHAT¹, SYED MANZOOR ALI², YOOSUF ALI ASHRAF MUHAMMAD HUSSENBOCUS³, AKANKSHA RATHI⁴, JAVAID AKHTER BHAT⁵, ABDUL ALEEM KHAN⁶, SYED MAQBOOL², RAJA SAQIB IQBAL⁷, MD MONOWARUL ISLAM⁸, YONGSHENG QU⁹, YOU ZHANG⁹, YUXIAO SUN¹, WENTAO XIAO⁹, ABHISHEK TIBREWAL¹⁰, CHUANYU GAO^1,*

1 Zhengzhou University People’s Hospital, Department of Cardiology, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China
2 Department of Cardiology, Super Speciality Division, Government Medical College, Srinagar, India
3 Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China
4 Department of Community Medicine, Vedanta Institute of Medical Sciences, Palghar, India
5 State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China
6 Department of Orthopaedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
7 Department of Paediatrics, Batra Hospital and Medical Research Centre, New Delhi, India
8 Zhengzhou University First Affiliated Hospital, Zhengzhou, China
9 Zhengzhou University People’s Hospital, Department of Cardiology, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China
10 Department of Community Medicine, Institute of Biostatistics and Epidemiology, Gurgaon, India

* Address correspondence to: Chuanyu Gao,

(This article belongs to the Special Issue: Cellular Biomechanics in Health and Diseases)

BIOCELL 2022, 46(5), 1139-1150. https://doi.org/10.32604/biocell.2022.016833

Received 30 March 2021; Accepted 13 August 2021; Issue published 06 January 2022

Abstract

The adverse outcomes of a ventricular heart failure (left, right or biventricular) caused by cardiogenic shock are aggravated by lung oedema and organ mal perfusion. Despite advances in medical sciences, revascularisation and mechanical hemodynamic support have proved ineffective in reducing the mortality rate in such patients. A thorough study of the data available about cardio-vascular diseases reveals that the application of conventional methods of treatment are least helpful to practically restore normal functions of heart when it experiences end-stage systolic ventricular failure. Thus, to overcome the challenges and find alternatives to address this issue, percutaneous ventricular support devices/machines were designed and successfully introduced. These devices have revolutionized the treatment of ventricular heart failures and are now in use all over the world. In this review paper a newer mechanical circulatory support (MCS) device, Impella, has been discussed and compared with a few other devices like (Intra-aortic Balloon Pump (IABP), Extracorporeal Circulation (ECLS) and Veno-arterial Extracorporeal Membrane Oxygenation (VA-ECMO). This article studies the challenges being faced during the treatment of cardiogenic shock, and thoroughly discusses the use and effectiveness of Impella Cardiac Axial Pump in each emergency. It can be said that mechanical circulatory support (MCS) device use during percutaneous coronary intervention (PCI) should be individualized based on multiple factors with a recommended use in patients with the greatest potential benefit and a relatively low risk of device-related complications. The current literature suggests that the outcomes of use of Impella and other mechanical circulatory support devices like IABP and VA-ECMO are comparable. Though there seem to be a few advantages of Impella over the others, sufficiently powered, multi-centric, randomised control trials are needed to establish its superiority.

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