Open Access

VIEWPOINT

Dental-derived stem cells and biowaste biomaterials: What’s next in bone regenerative medicine applications

MICHELE DI COSOLA^1,§; STEFANIA CANTORE^2,§,*; MARIO GIOSUÈ BALZANELLI³; CIRO GARGIULO ISACCO^2,3; KIEU CAO DIEM NGUYEN^2,3; RAJIV SAINI²; ANNARITA MALCANGI⁴; MARGHERITA TUMEDEI⁵; MARIATERESA AMBROSINO¹; ANTONIO MANCINI²; SALVATORE SCACCO⁶; RICCARDO NOCINI⁷; LUIGI SANTACROCE²; ANDREA BALLINI^8,9,#,*; EDOARDO BRAUNER^10,#

1 Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, 71122, Italy
2 Department Interdisciplinary of Medicine, University of Bari “Aldo Moro”, Bari, 70124, Italy
3 SET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, Taranto, 74010, Italy
4 Azienda Sanitaria Locale BAT, Trani, 76125, Italy
5 Department of Medical, Oral and Biotechnological Sciences, University of Chieti, Chieti, 66100, Italy
6 Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, Bari, 70124, Italy
7 Department of Surgical Sciences, Dentistry, Gynecology and Pediatric, University of Verona, Verona, 37126, Italy
8 School of Medicine, University of Bari “Aldo Moro”, Bari, 70124, Italy
9 Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, 80138, Italy
10 Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Roma, 00161, Italy
§ Contributed equally as co-first authors
# Contributed equally as co-last authors

* Corresponding Authors:ANDREA BALLINI. Email: ; STEFANIA CANTORE. Email:

BIOCELL 2022, 46(4), 923-929. https://doi.org/10.32604/biocell.2022.018409

Received 06 August 2021; Accepted 23 September 2021; Issue published 15 December 2021

Abstract

The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs), so called dental-derived stem cells (D-dSCs) with self-renewing and multilineage differentiation capabilities. D-dSCs properties involves a strong paracrine component resulting from the high levels of bioactive molecules they secrete in response to the local microenvironment. Altogether, this viewpoint develops a general picture of current innovative strategies to employ D-dSCs combined with biomaterials and bioactive factors for regenerative medicine purposes, and offers information regarding the available scientific data and possible applications.

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