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Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach

EJLAL ABU-EL-RUB1,2,*, RAMADA R. KHASAWNEH1, FATIMAH A. ALMAHASNEH1, HANA M. ZEGALLAI3,4

1 Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 21163, Jordan
2 Physiology and Pathophysiology, Faculty of Medicine, University of Manitoba, Winnipeg, R3E0W2, Canada
3 Department of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, R3E0W2, Canada
4 DREAM, Children’s Hospital Research Institute of Manitoba, Winnipeg, R3E0W2, Canada

* Corresponding Author: EJLAL ABU-EL-RUB. Email: email

BIOCELL 2022, 46(4), 907-911. https://doi.org/10.32604/biocell.2022.018306

Abstract

The paracrine and immunomodulatory cytokines secreted by mesenchymal stem cells (MSCs), generally referred to as the MSCs derived secretome, has substantial potential for the treatment of many chronic and degenerative diseases. MSCs secretome contains both common and disease specific cytokines and modulators that can be beneficial against a wide range of chronic diseases. Herein, we discuss the MSCs secretome composition profile and its translational applicability and the challenges surrounding its use in clinical settings.

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APA Style
ABU-EL-RUB, E., KHASAWNEH, R.R., ALMAHASNEH, F.A., ZEGALLAI, H.M. (2022). Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach. BIOCELL, 46(4), 907-911. https://doi.org/10.32604/biocell.2022.018306
Vancouver Style
ABU-EL-RUB E, KHASAWNEH RR, ALMAHASNEH FA, ZEGALLAI HM. Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach. BIOCELL . 2022;46(4):907-911 https://doi.org/10.32604/biocell.2022.018306
IEEE Style
E. ABU-EL-RUB, R.R. KHASAWNEH, F.A. ALMAHASNEH, and H.M. ZEGALLAI, “Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach,” BIOCELL , vol. 46, no. 4, pp. 907-911, 2022. https://doi.org/10.32604/biocell.2022.018306



cc Copyright © 2022 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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