Open Access

ARTICLE

LINC complex independent perinuclear actin organization and cell migration

ANDREA FRACCHIA^1,2, GABI GERLITZ^1,*

1 Department of Molecular Biology, Faculty of Life Sciences and Ariel Center for Applied Cancer Research, Ariel University, Ariel, 40700, Israel
2 Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah Medical Organization, Jerusalem, 91120, Israel

* Corresponding Author: GABI GERLITZ. Email:

BIOCELL 2022, 46(4), 931-935. https://doi.org/10.32604/biocell.2022.018179

Received 05 July 2021; Accepted 08 September 2021; Issue published 15 December 2021

Abstract

The link of the metazoan nucleus to the actin cytoskeleton is highly important for actin polymerization and migration of multiple cell types as well as for mechanotransduction and even affects the cellular transcriptome. Several mechanisms of organization of actin filaments next to the nuclear envelope have been identified. Among these mechanisms the most studied one is the Linker of nucleoskeleton and cytoskeleton (LINC) complex-dependent perinuclear actin organization. However, recently additional mechanisms have been identified: an Actin-related protein-2/3 (Arp2/3)-dependent perinuclear actin polymerization during migration of dendritic cells and a perinuclear actin rim that is formed in response to external force application or migration cues. In parallel, there are also reports on cancer cells that migrate in a LINC complex independent manner and on cancers with reduced expression of the LINC complex components. Thus, suggesting that LINC complex independent migration may be associated with tumour formation.

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