Open Access

REVIEW

Study of cytoskeleton from microscopic point of view: Our experience

CINZIA SIGNORINI^*, GIULIA COLLODEL, ELENA MORETTI

Department of Molecular and Developmental Medicine of University of Siena, Siena, I-53100, Italy

* Corresponding Author:CINZIA SIGNORINI. Email:

BIOCELL 2022, 46(4), 881-884. https://doi.org/10.32604/biocell.2022.018062

Received 25 June 2021; Accepted 13 August 2021; Issue published 15 December 2021

Abstract

The manuscript deals with our studies and experiences in the assessment of cytoskeleton in different cellular models and situations. The immunofluorescent study of several cytoskeletal proteins was relevant in the evaluation of a therapy for osteoarthritis, in case of alkaptonuria and in testing the efficacy of docetaxel in neuroblastoma cancer cells leading to apoptosis. A relevant part of our experience focus on the study of cytoskeleton in seminiferous epithelium and spermatozoa, identifying alterations affecting blood-testis barrier after a silver nanoparticle treatment, chromosomal segregation in case of varicocele, sperm motility and diagnosing systematic sperm defects as “Primary ciliary dyskinesia” and “Dysplasia of the fibrous sheath”. The evaluation of cytoskeleton represents a specific and sensitive analysis in establishing the health status of different cells.

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