Open Access

ARTICLE

Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways

TIANTIAN XU^1,#, RUILIN ZHENG^1,#, DANYANG CHEN^1,#, HAIYANG CHEN², MINGQI ZHAO¹, MIN GUO¹, YI CHEN¹, CHANGBING WANG¹, LU KUANG¹, YINGHUA LI^1,*, BING ZHU^1,*

1 Center Laboratory, Guangzhou Women and Children’s Medical Center, Medical University, Guangzhou, 510120, China
2 Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

* Corresponding Authors: YINGHUA LI. Email: ; BING ZHU. Email:
# These authors contributed equally to this work

BIOCELL 2022, 46(4), 1033-1039. https://doi.org/10.32604/biocell.2022.017757

Received 04 June 2021; Accepted 14 August 2021; Issue published 15 December 2021

Abstract

Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor that can prevent apoptosis. The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs. In this study, after treated with ZVAD in EV-A71 infected Vero cells, the viral replication was reduced, and the cell viability was higher than EV-A71 group. Additionally, ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells. ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral.

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