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Short term protective effect of digitoxin in sepsis-induced acute lung injury

EJDER SAYLAV BORA1,*, MüMIN ALPER ERDOĞAN2, BAHATTIN ÖZKUL3, İBRAHIM HALIL SEVER4, İBRAHIM SÖĞÜT5, CANAN HÜRDAĞ6, OYTUN ERBAŞ7

1 İzmir Atatürk Research and Training Hospital Emergency Medicine, Izmir, Turkey
2 Department of Physiology, İzmir Katip Çelebi University, Izmir, Turkey
3 Department of Radiology, Istanbul Atlas University, Istanbul, Turkey
4 Department of Radiology, Demiroğlu Bilim University, Istanbul, Turkey
5 Department of Biochemistry, Demiroğlu Bilim University, Istanbul, Turkey
6 Department of Histology and Embryology, Demiroğlu Bilim University, Istanbul, Turkey
7 Department of Physiology, Demiroğlu Bilim University, Istanbul, Turkey

* Corresponding Author: EJDER SAYLAV BORA. Email: email

BIOCELL 2022, 46(2), 433-439. https://doi.org/10.32604/biocell.2022.018510

Abstract

Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known anti-inflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury (ALI). Method: 28 wistar albino rats were divided into 4 groups. Sepsis model is performed by the feces intraperitoneal-injection procedure (FIP). Results: TNF-a, CRP, IL-6, IL 1-Beta, lactic acid, and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group. When the same groups were examined, histological improvements such as decrease in alveolar inflammation and decrease in septal thickening in the digitoxin group and thorax CT were found to be significantly higher in the Hounsfield unit digitoxin group compared to the Saline group. Conclusion: Digitoxin has shown biochemical improvement in sepsis with all known mechanisms of action, and healing effects in both computerized tomography and histology in the lung.

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APA Style
BORA, E.S., ERDOĞAN, M.A., ÖZKUL, B., SEVER, İ.H., SÖĞÜT, İ. et al. (2022). Short term protective effect of digitoxin in sepsis-induced acute lung injury. BIOCELL, 46(2), 433-439. https://doi.org/10.32604/biocell.2022.018510
Vancouver Style
BORA ES, ERDOĞAN MA, ÖZKUL B, SEVER İH, SÖĞÜT İ, HÜRDAĞ C, et al. Short term protective effect of digitoxin in sepsis-induced acute lung injury. BIOCELL . 2022;46(2):433-439 https://doi.org/10.32604/biocell.2022.018510
IEEE Style
E.S. BORA et al., “Short term protective effect of digitoxin in sepsis-induced acute lung injury,” BIOCELL , vol. 46, no. 2, pp. 433-439, 2022. https://doi.org/10.32604/biocell.2022.018510

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cc Copyright © 2022 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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