Open Access

ARTICLE

Diagnostic and prognostic significance of the lymphocyte/C-reactive protein ratio, neutrophil/lymphocyte ratio, and D-dimer values in patients with COVID-19

by ALPASLAN OZTURK^1,*, MEHMET KARA²

1 Department of Medical Biochemistry, Amasya University Faculty of Medicine, Amasya, 05000, Turkey
2 Department of Infectious Diseases and Clinical Microbiology, Beylikduzu State Hospital, Istanbul, 34000, Turkey

* Corresponding Author: ALPASLAN OZTURK. Email:

(This article belongs to the Special Issue: Biochemical and Epigenetics Changes in Health and Disease)

BIOCELL 2022, 46(12), 2625-2635. https://doi.org/10.32604/biocell.2022.023124

Received 11 April 2022; Accepted 24 May 2022; Issue published 10 August 2022

Abstract

In this study, our aim was to examine the diagnostic and prognostic significance of lymphocyte/C-reactive protein ratio (LCR), neutrophil/lymphocyte ratio (NLR) and D-dimer parameters in COVID-19 infection. The LCR, NLR, neutrophil count, mean platelet volume (MPV), C-reactive protein (CRP), and D-dimer parameters were evaluated retrospectively. This was a retrospective cohort study with 1000 COVID-19 positive and 1000 healthy control groups, all over the age of 18 years. Odds ratio (OR) and 95% confidence interval (CI) values were calculated for each parameter found to be statistically significant in the univariate and multivariate logistic regression models. Herein, 127 (12.7%) of the COVID-19⁺ patients, whose data was included in this study, died. The neutrophil, MPV, CRP, D-dimer, and NLR values were higher in the COVID-19⁺/deceased group than in the COVID-19⁺/alive and control groups (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001). The lymphocyte and LCR values were lower in the COVID-19⁺/deceased group than in the COVID-19⁺/alive and control groups (p < 0.001, p < 0.001). Variables with statistically significance in predicting COVID-19 infection were lymphocyte, LCR, D-dimer, NLR, CRP, MPV, PLT, and neutrophil values. Statistically significant variables in predicting mortality due to COVID-19 were LCR, CRP, NLR, lymphocyte, D-dimer, neutrophil, and MPV values. A low LCR and high NLR are associated with the presence, prognosis, and mortality due to COVID-19. LCR and NLR parameters can thus be used in clinical monitoring to reduce morbidity and mortality rates.

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Keywords

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