Open Access

REVIEW

Aptamer based detection and separation platforms for ochratoxin A: A systematic review

RAHELEH TORABI¹, ABBAS ALI REZVANIPOUR², HADI ESMAEILI GOUVARCHINGHALEH³, REZA RANJBAR^4,*, MOHAMMAD HEIAT^2,*

1 Laboratory of Bioanalysis, Institute of Biochemistry & Biophysics, University of Tehran, Tehran, Iran
2 Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, Iran
3 Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
4 Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

* Corresponding Authors: REZA RANJBAR. Email: ; MOHAMMAD HEIAT. Email:

BIOCELL 2022, 46(12), 2537-2557. https://doi.org/10.32604/biocell.2022.021373

Received 11 January 2022; Accepted 11 April 2022; Issue published 10 August 2022

Abstract

Ochratoxin A (OTA), one of the most dangerous mycotoxins for human health, has been subjected to numerous studies for separation and detection in minimal amounts. Aptamers as novel recognition elements have been employed to fabricate ultrasensitive biosensors for the detection of OTA and designing delicate analytical tools. This review attempted to comprehensively examine all reported aptamer-based detection and separation platforms for ochratoxin. The most relevant databases were considered to discover all specific aptamers for dealing with OTA. Aptamer-based detection and separation devices specified for OTA were searched for, analyzed, discussed, and classified based on their specifications. The optical aptasensors have gathered a higher interest than electrochemical aptasensors, which can achieve a lower limit of detections. Moreover, some extraction platforms based on these aptamers were also found. However, aptamer-based devices seem to have some challenges in their application.

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Keywords

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