Open Access

REVIEW

Biomechanics of transendothelial migration by cancer cells

by CLAUDE VERDIER^*

Université Grenoble Alpes, CNRS, LIPhy, Grenoble, 38000, France

* Corresponding Author: CLAUDE VERDIER. Email:

(This article belongs to the Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)

BIOCELL 2022, 46(11), 2381-2386. https://doi.org/10.32604/biocell.2022.021368

Received 15 January 2022; Accepted 27 April 2022; Issue published 07 July 2022

Abstract

Cancer metastasis is still a major social issue with limited knowledge of the formation of tumors and their growth. In addition the formation of metastases is very difficult to understand, since it involves very complex physical mechanisms such as cellular interactions and cell rheology, which are flow-dependent. Previous studies investigated transendothelial migration using sophisticated techniques such as microfluidics, traction force microscopy (TFM) or Atomic Force Microscopy (AFM), combined with physical modeling. Here we summarize recent results and suggest new ways to investigate the precise mechanisms used by cancer cells to undergo transendothelial migration.

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Keywords

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