Open Access

REVIEW

Effect of demethyltransferase FTO on tumor progression

by LING SHENG^1,2, YUEHONG SHEN^1,2, HONGYU YANG^1,2,*

1 School of Stomatology, Weifang Medical University, Weifang, 261035, China
2 Department of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University, Shenzhen, 518036, China

* Corresponding Author: HONGYU YANG. Email:

(This article belongs to the Special Issue: Recent Advancement in Cancer Molecular Signaling)

BIOCELL 2022, 46(11), 2387-2397. https://doi.org/10.32604/biocell.2022.021032

Received 27 December 2021; Accepted 10 March 2022; Issue published 07 July 2022

Abstract

N⁶-methyladenosine (m⁶A) modification is the most widespread and conserved internal mRNA modification in mammalian cells. It greatly affects genetic regulation by enhancing the involvement of diverse cellular enzymes and thus, plays a significant role in basic life processes. Numerous studies on m⁶A modification identified FTO as a crucial demethylase that participates in various biological processes. Not only does FTO play a pivotal role in obesity-related conditions, but it also influences the occurrence, development, and prognosis of several cancers, such as acute myeloid leukemia, breast cancer, liver cancer, and lung cancer. Moreover, FTO also shows a close association with immunity and viral infections. This article summarized the molecular mechanism of FTO in tumorigenesis and tumor progression.

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Keywords

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