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Ready to migrate? Reading cellular signs of migration in an epithelial to mesenchymal transition model

by TAMARA FERNÁNDEZ-CALERO^1,2,3,#, IGNACIO LÓPEZ^1,#, MARCOS DAVYT¹, CORA CHALAR¹, RICARDO EHRLICH^1,4, MÓNICA MARÍN^1,*

1 Biochemistry-Molecular Biology, Faculty of Science, Universidad de la República, Montevideo, 11400, Uruguay
2 Bioinformatics Unit, Institut Pasteur de Montevideo, Montevideo, 11400, Uruguay
3 Departamento de Ciencias Exactas y Naturales, Universidad Católica del Uruguay, Montevideo, 11600, Uruguay
4 Institut Pasteur de Montevideo, Montevideo, 11400, Uruguay

* Corresponding Author: MÓNICA MARÍN. Email:

(This article belongs to the Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)

BIOCELL 2022, 46(11), 2353-2356. https://doi.org/10.32604/biocell.2022.020966

Received 31 December 2021; Accepted 18 March 2022; Issue published 07 July 2022

Abstract

The epithelial to mesenchymal transition (EMT) is a cellular program that drives de-differentiation of cells in both physiological and pathological processes. One of the characteristics of cells describing an EMT is the (re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the organism. The molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with a high demand of extracellular components.

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