@Article{biocell.2022.019916, AUTHOR = {SANHUA LI, QINGHONG KONG, XIAOKE ZHANG, XINTING ZHU, CHUNBO YU, CHANGYAN YU, NIAN JIANG, JING HUI, LINGJIE MENG, YUN LIU,}, TITLE = {3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway}, JOURNAL = {BIOCELL}, VOLUME = {46}, YEAR = {2022}, NUMBER = {11}, PAGES = {2425--2432}, URL = {http://www.techscience.com/biocell/v46n11/48769}, ISSN = {1667-5746}, ABSTRACT = {Traditional Chinese medicine (TCM) has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers. 3-epi-bufotalin is an active ingredient of TCM “Chanpi” with anti-tumor potential. However, the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed. The present study demonstrated that 3-epi-bufotalin could reduce viability, trigger apoptosis, and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29, RKO, and COLO205 in vitro. Moreover, 3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway. These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells.}, DOI = {10.32604/biocell.2022.019916} }