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XINXING YANG^*, RUIJIAO LIU
BIOCELL, Vol.46, No.11, pp. 2343-2351, 2022, DOI:10.32604/biocell.2022.022100 - 07 July 2022
Abstract Most bacteria assemble a ring-like macromolecular machinery scaffolded by the essential cytoskeletal protein FtsZ for cell division. Studies have broadly explored how FtsZ could polymerize at the correct place and time. Recently, the FtsZ-ring was found to exhibit dynamic treadmilling along the circumference of the division site, driven by GTP hydrolysis. This apparently directional motion of FtsZ seems to drive the movement of septal cell wall synthesis enzymes and to play an important role in modulating cell envelope constriction and septum morphogenesis. However, the relationship between FtsZ’s treadmilling dynamics and cell wall synthesis varies in More >

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TAMARA FERNÁNDEZ-CALERO^1,2,3,#, IGNACIO LÓPEZ^1,#, MARCOS DAVYT¹, CORA CHALAR¹, RICARDO EHRLICH^1,4, MÓNICA MARÍN^1,*
BIOCELL, Vol.46, No.11, pp. 2353-2356, 2022, DOI:10.32604/biocell.2022.020966 - 07 July 2022
（This article belongs to the Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)
Abstract The epithelial to mesenchymal transition (EMT) is a cellular program that drives de-differentiation of cells in both physiological and pathological processes. One of the characteristics of cells describing an EMT is the (re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the organism. The molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with More >

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540

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CHUYING ZHOU¹, MINEKO KENGAKU^1,2,*
BIOCELL, Vol.46, No.11, pp. 2357-2361, 2022, DOI:10.32604/biocell.2022.021050 - 07 July 2022
（This article belongs to the Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)
Abstract Neuronal migration is a fundamental process of mammalian brain development. In migrating neurons, the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor to pull the nucleus along microtubule tracks. Current evidence has shown that Nesprin-2 binds to both the minus-end-directed motor dynein as well as the plus-end-directed motor kinesin. However, translocation of neuronal nucleus has long been thought to be primarily driven by dynein motors. Intriguing questions could be raised about the role of kinesin in nuclear transport and how the activities of opposing motors are coordinated through interactions with Nesprin. More >

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TRINIDAD MONTERO-VILCHEZ^1,2,*, MANUEL SANCHEZ-DIAZ^1,2, CAROLINA MONTERO-VILCHEZ³, ALVARO SIERRA-SANCHEZ², SALVADOR ARIAS-SANTIAGO^1,2,4
BIOCELL, Vol.46, No.11, pp. 2363-2367, 2022, DOI:10.32604/biocell.2022.021399 - 07 July 2022
Abstract Atopic dermatitis (AD) is a chronic cutaneous inflammatory disease caused by an interaction between genetic, immune and epidermal barrier factors. Several treatments can be used to treat this disease but there are patients that do not respond to actual drugs. So, there is a need to develop effective therapies for AD. Mesenchymal stem cells (MSCs) are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage, so they could be a potential effective treatment for AD. MSCs-Conditioned Medium (CM) and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells More >

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LORIS RIZZELLO^1,2,3, VALERIA DE MATTEIS^4,*
BIOCELL, Vol.46, No.11, pp. 2369-2380, 2022, DOI:10.32604/biocell.2022.021059 - 07 July 2022
Abstract The SARS-CoV-2 outbreaks highlighted the need for effective, reliable, fast, easy-to-do and cheap diagnostics procedures. We pragmatically experienced that an early positive-case detection, inevitably coupled with a mass vaccination campaign, is a milestone to control the COVID-19 pandemic. Gold nanoparticles (AuNPs) can indeed play a crucial role in this context, as their physicochemical, optics and electronics properties are being extensively used in photothermal therapy (PTT), radiation therapy (RT), drug delivery and diagnostic. AuNPs can be synthesized by several approaches to obtain different sizes and shapes that can be easily functionalized with many kinds of molecules More >

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REVIEW

CLAUDE VERDIER^*
BIOCELL, Vol.46, No.11, pp. 2381-2386, 2022, DOI:10.32604/biocell.2022.021368 - 07 July 2022
（This article belongs to the Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)
Abstract Cancer metastasis is still a major social issue with limited knowledge of the formation of tumors and their growth. In addition the formation of metastases is very difficult to understand, since it involves very complex physical mechanisms such as cellular interactions and cell rheology, which are flow-dependent. Previous studies investigated transendothelial migration using sophisticated techniques such as microfluidics, traction force microscopy (TFM) or Atomic Force Microscopy (AFM), combined with physical modeling. Here we summarize recent results and suggest new ways to investigate the precise mechanisms used by cancer cells to undergo transendothelial migration. More >

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652

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LING SHENG^1,2, YUEHONG SHEN^1,2, HONGYU YANG^1,2,*
BIOCELL, Vol.46, No.11, pp. 2387-2397, 2022, DOI:10.32604/biocell.2022.021032 - 07 July 2022
（This article belongs to the Special Issue: Recent Advancement in Cancer Molecular Signaling)
Abstract N⁶-methyladenosine (m⁶A) modification is the most widespread and conserved internal mRNA modification in mammalian cells. It greatly affects genetic regulation by enhancing the involvement of diverse cellular enzymes and thus, plays a significant role in basic life processes. Numerous studies on m⁶A modification identified FTO as a crucial demethylase that participates in various biological processes. Not only does FTO play a pivotal role in obesity-related conditions, but it also influences the occurrence, development, and prognosis of several cancers, such as acute myeloid leukemia, breast cancer, liver cancer, and lung cancer. Moreover, FTO also shows a close association More >

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636

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KE JIA¹, FU-QING TAN², SHUANG-LI HAO^1,*, WAN-XI YANG^1,*
BIOCELL, Vol.46, No.11, pp. 2399-2413, 2022, DOI:10.32604/biocell.2022.022015 - 07 July 2022
Abstract The SRY-related high mobility group (HMG) box (SOX) transcription factors participate in many physiological processes of animal growth, development, and reproduction and are related to spermatogenesis in many species. However, the relationship between SOX and spermatogenesis in Eriocheir sinensis is rarely reported. Here, we studied the role of Es-SOX8 in the spermatogenesis of E. sinensis and its possible regulation mechanism. Immunofluorescence results demonstrated Es-SOX8 signal in both cytoplasm and nucleus of spermatogonia, spermatocytes as well as spermatids, but not in mature spermatozoa. Hematoxylin and eosin staining showed a significant increase in the number of spermatozoa with abnormal… More >

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781

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CHANG CHEN^1,#, LIMIN QIAO^2,#, KAIJUN GUO¹, YINGQIU WANG¹, MENGYI YUAN³, BOFAN FU⁴, XIAOBO GAO³, HEMIN NI¹, LONGFEI XIAO^1,*, XIANGGUO WANG^1,*
BIOCELL, Vol.46, No.11, pp. 2415-2423, 2022, DOI:10.32604/biocell.2022.021510 - 07 July 2022
（This article belongs to the Special Issue: Decoding Gene (including circRNA, lincRNA miRNA and mRNA) Expression)
Abstract Endometritis affects the reproductive capacity of dairy cows and leads to serious economic losses in dairy farming. Clarification of the pathogenesis of endometritis is necessary to improve the reproductive efficiency of dairy cows. Exosomes and their miRNAs have been proven to play an important role in inflammatory regulation. Exosomal miR-218 is a differentially expressed miRNA found in endometrial epithelial cells (EECs) under endometrial inflammation. Therefore, we investigated the expression of miR-218 in the uterine tissue of dairy cows, lipopolysaccharide (LPS) treated EECs, exosomal vesicles, and regulation of exosomal miR-218 by targeting TGIF-2 inducible factor homology… More >

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796

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SANHUA LI^1,2,#, QINGHONG KONG^1,2,#, XIAOKE ZHANG^1,2, XINTING ZHU^1,3, CHUNBO YU³, CHANGYAN YU^1,2, NIAN JIANG^1,2, JING HUI^1,2, LINGJIE MENG^1,2,*, YUN LIU^1,2,3,*
BIOCELL, Vol.46, No.11, pp. 2425-2432, 2022, DOI:10.32604/biocell.2022.019916 - 07 July 2022
（This article belongs to the Special Issue: Recent Advancement in Cancer Molecular Signaling)
Abstract Traditional Chinese medicine (TCM) has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers. 3-epi-bufotalin is an active ingredient of TCM “Chanpi” with anti-tumor potential. However, the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed. The present study demonstrated that 3-epi-bufotalin could reduce viability, trigger apoptosis, and block the cell cycle at the G₂/M stage in colorectal cancer cell lines HT29, RKO, and COLO205 in vitro. Moreover, 3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway. These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells. More >

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694

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ARTICLE

TIANTIAN ZHOU^1,3,#, YUMEI ZHANG^1,2,#, JUAN ZHANG^1,2, CHUNYAN XIE², ZHENYA ZHAI^1,2, XIN WU^1,2,3,*
BIOCELL, Vol.46, No.11, pp. 2433-2442, 2022, DOI:10.32604/biocell.2022.021290 - 07 July 2022
Abstract High-fat diet (HFD) is demonstrated to disturb the bile acid metabolism. The rhythm of bile acid metabolism can also be affected by uridine, whose metabolism exhibits a daily rhythm. However, the mechanism of dynamic uridine administration affecting bile acid during HFD remains unclear. In this study, C57BL/6J mice were fed HFD (the control group; CON) or HFD with oral administration of uridine in the daytime (DUR) and nighttime (NUR) to investigate the mechanism of the effect of uridine on the bile acid. This study showed that the mRNA expression of uridine transporters and circadian clock… More >

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ABDELAZIZ ADAM IDRISS ARBAB^1,3,#, CHUNQING YIN^4,#, XUBIN LU¹, YAN LIANG¹, ISMAIL MOHAMED ABDALLA¹, AMER ADAM IDRIS³, TIANLE XU^1,2, YONGJIANG MAO¹, ZHANGPING YANG^1,2,*
BIOCELL, Vol.46, No.11, pp. 2443-2454, 2022, DOI:10.32604/biocell.2022.020865 - 07 July 2022
（This article belongs to the Special Issue: Decoding Gene (including circRNA, lincRNA miRNA and mRNA) Expression)
Abstract Mastitis is a common inflammatory cow mammary infection; that causes significant economic loss in dairy industry. Given the interesting connection between metformin’s anti-inflammatory function and mastitis model induced by LTA in pbMECs, our objective was to prove that metformin was beneficial in suppressing proinflammatory response induced by LTA through modulation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways and activation of peroxisome proliferator-activated receptor-γ (PPARγ) in pbMECs. The proliferation of cells and mRNA expression were measured using EdU assay and quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Immunoblotting and immunofluorescence analysis… More >

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968

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RUICONG GUAN^1,3,#, KUAN ZENG^1,#, MINNAN GAO¹, JIANFEN LI¹, HUIQI JIANG¹, LU ZHANG¹, JINGWEN LI¹, BIN ZHANG¹, YUQIANG LIU¹, ZHUXUAN LIU¹, DIAN WANG¹, YANQI YANG^1,2,*
BIOCELL, Vol.46, No.11, pp. 2455-2463, 2022, DOI:10.32604/biocell.2022.021661 - 07 July 2022
Abstract Bone marrow mesenchymal stem cell (MSC)-based therapy is a novel candidate for heart repair. But ischemia-reperfusion injury leads to low viability of MSC. Dexmedetomidine (Dex) has been found to protect neurons against ischemia-reperfusion injury. It remains unknown if Dex could increase the viability of MSCs under ischemia. The present study is to observe the potential protective effect of Dex on MSCs under ischemia and its underlying mechanisms. Specific mRNAs related to myocardial ischemia in the GEO database were selected from the mRNA profiles assessed in a previous study using microarray. The most dysregulated mRNAs of… More >

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748

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YUNHUI ZHOU, YAJIE LIU, WENNA ZHAO, FEI CHEN, YUDAN WANG, CHUNXUE YANG
BIOCELL, Vol.46, No.11, pp. 2465-2474, 2022, DOI:10.32604/biocell.2022.021016 - 07 July 2022
（This article belongs to the Special Issue: Mycorrhizal Fungal Roles in Stress Tolerance of Plants)
Abstract Salinization has led to the deterioration of the ecological environment, affected the growth of plants, and hindered the development of agriculture and forestry. Arbuscular mycorrhizal (AM) fungi, as important soil microorganisms, play significant physiological and ecological roles in promoting plant nutrient absorption and improving soil structure. Puccinellia tenuiflora (Turcz.) Scribn. et Merr. in Songnen saline-alkaline grassland was selected as the research object to observe AM fungal colonization of the roots and explore the species and diversity of AM fungi in symbiotic association with P. tenuiflora. This study showed that AM fungi colonized in P. tenuiflora roots and formed… More >

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ARTICLE

YAJIE LIU, LINLIN FANG, CHUNXUE YANG^*
BIOCELL, Vol.46, No.11, pp. 2475-2488, 2022, DOI:10.32604/biocell.2022.021477 - 07 July 2022
（This article belongs to the Special Issue: Mycorrhizal Fungal Roles in Stress Tolerance of Plants)
Abstract Arbuscular mycorrhizal (AM) fungi are widely distributed in various habitats, and the community composition varies in response to the changing environmental conditions. To explore the response of community composition to the succession of saline-alkali land, soil samples were collected from three succession stages of Songnen saline-alkali grassland. Subsequently, the soil characteristics were determined and the AM fungi in soil samples were analyzed by high-throughput sequencing. Then, the response relationship between community composition and soil characteristics was studied by Canonical correlation and Pearson analyses. The soil properties improved with the succession of saline-alkali grassland. There was… More >

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876

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ARTICLE

XIAOJUN ZHOU^*, XIAOYU LU, XUBO WANG
BIOCELL, Vol.46, No.11, pp. 2489-2495, 2022, DOI:10.32604/biocell.2022.020311 - 07 July 2022
Abstract Euptelea pleiosperma is a characteristic species of East Asian flora with both ornamental and scientific values. Based on the reduced-representation sequencing (RRS) technology of RAD-Seq, this study conducted high-throughput Illumina paired-end sequencing to find SSR marker information in the genome of E. pleiosperma, and to screen and verify polymorphism of SSR markers. We obtained 5.5G of high-quality data using RAD-Seq. The total number of contigs of the RAD tags was 299,376, with the maximum contig length of 2,062 bp and the average length of 445 bp. From these sequences, we identified 20,718 SSR loci, with a distribution… More >

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YOLANDA GONZÁLEZ-GARCÍA¹, VALERIA FLORES-ROBLES², GREGORIO CADENAS-PLIEGO³, ADALBERTO BENAVIDES-MENDOZA⁴, MARCELINO CABRERA DE LA FUENTE⁴, ALBERTO SANDOVAL-RANGEL⁴, ANTONIO JUÁREZ-MALDONADO^1,*
BIOCELL, Vol.46, No.11, pp. 2497-2506, 2022, DOI:10.32604/biocell.2022.021861 - 07 July 2022
（This article belongs to the Special Issue: Physiology and Molecular Biology of Plant Stress Tolerance)
Abstract The metabolic activity of the fruits continues even after harvest, which results in the loss of bioactive compounds, a decrease in the quality of the fruits, softening and browning, among other negative effects. The use of certain elements such as silicon can improve postharvest quality, since it is involved in the metabolic, physiological and structural activity of plants, moreover can increase the quality of the fruits. In addition, nanotechnology has had a positive impact on crop yield, nutritional value, fruit quality and can improve antioxidant activity. For these reasons, the use of beneficial elements such… More >

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828

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TINGTING HUANG^1,#, SHAN DENG^2,#, JIANGYUAN SHENG¹, DI ZHANG^1,*
BIOCELL, Vol.46, No.11, pp. 2507-2515, 2022, DOI:10.32604/biocell.2022.021314 - 07 July 2022
（This article belongs to the Special Issue: Physiology and Molecular Biology of Plant Stress Tolerance)
Abstract Dehydrins (DHNs), as members of the late embryogenesis abundant protein family, play critical roles in the protection of seeds from dehydration and plant adaptation to multiple abiotic stresses. Vitrification is a basic method in plant cryopreservation and is characterized by forming a glassy state to prevent lethal ice crystals produced during cryogenic storage. In this study, ApSK₃ type DHN was genetically transformed into embryogenic calluses (EC) of Agapanthus praecox by overexpression (OE) and RNA interference (RNAi) techniques to evaluate the in vivo protective effect of DHNs during cryopreservation. The cell viability showed a completely opposite trend in OE… More >

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