@Article{biocell.2022.021161, AUTHOR = {BING WANG, KAORU TANAKA, KOUICHI MARUYAMA, YASUHARA NINOMIYA, TAKANORI KATSUBE, MITSURU NENOI}, TITLE = {Induction of adaptive response in utero by ionizing radiation: A radiation quality dependent phenomenon}, JOURNAL = {BIOCELL}, VOLUME = {46}, YEAR = {2022}, NUMBER = {10}, PAGES = {2315--2325}, URL = {http://www.techscience.com/biocell/v46n10/48225}, ISSN = {1667-5746}, ABSTRACT = {Investigation on possible induction of adaptive response (AR) by high-liner energy transfer (LET) particle radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in utero. This study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions against low-LET X-ray radiation-induced detrimental effects on fetal mice. Total body irradiation of pregnant C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray radiation. The monoenergetic beams of carbon, silicon and iron with the LET values of about 15, 55, and 200 KeV/μm, respectively, were examined. Significant suppression by the priming radiation of the detrimental effects (fetal death, malformation, or low body weight) was used as the endpoints for judgment of a successful AR induction on gestation day 18. Existence of AR was not observed. On the other hand, the priming dose of high-LET particle radiation, in some cases, even increased the detrimental effects induced by the challenge dose from low-LET X-ray radiation. Although existence of AR induced by high-LET radiation in cultured mammalian cells in vitro and in certain tissues of laboratory mice in vivo was demonstrated, the present study did not suggest that low dose of high-LET particle radiation could induce an AR in fetal mice in utero under the setup of our experimental system.}, DOI = {10.32604/biocell.2022.021161} }