@Article{biocell.2022.021161,
AUTHOR = {BING WANG, KAORU TANAKA, KOUICHI MARUYAMA, YASUHARA NINOMIYA, TAKANORI KATSUBE, MITSURU NENOI},
TITLE = {Induction of adaptive response in utero by ionizing radiation: A radiation quality dependent phenomenon},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {10},
PAGES = {2315--2325},
URL = {http://www.techscience.com/biocell/v46n10/48225},
ISSN = {1667-5746},
ABSTRACT = {Investigation on possible induction of adaptive response (AR) by high-liner energy transfer (LET) particle
radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in
utero. This study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions
against low-LET X-ray radiation-induced detrimental effects on fetal mice. Total body irradiation of pregnant
C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation
on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray radiation. The monoenergetic
beams of carbon, silicon and iron with the LET values of about 15, 55, and 200 KeV/μm, respectively, were examined.
Significant suppression by the priming radiation of the detrimental effects (fetal death, malformation, or low body
weight) was used as the endpoints for judgment of a successful AR induction on gestation day 18. Existence of AR
was not observed. On the other hand, the priming dose of high-LET particle radiation, in some cases, even increased
the detrimental effects induced by the challenge dose from low-LET X-ray radiation. Although existence of AR
induced by high-LET radiation in cultured mammalian cells in vitro
and in certain tissues of laboratory mice in vivo
was demonstrated, the present study did not suggest that low dose of high-LET particle radiation could induce an AR
in fetal mice in
utero under the setup of our experimental system.},
DOI = {10.32604/biocell.2022.021161}
}