TY - EJOU AU - NETTI, GIUSEPPE STEFANO AU - SPADACCINO, FEDERICA AU - CATALANO, VALERIA AU - CASTELLANO, GIUSEPPE AU - STALLONE, GIOVANNI AU - RANIERI, ELENA TI - Role of PTX3 and complement modulation in the tumor microenvironment T2 - BIOCELL PY - 2022 VL - 46 IS - 10 SN - 1667-5746 AB - Pentraxin-3 (PTX3), the prototype of long pentraxins, seems to influence complement system (CS) modulation. PTX3 and CS sustain carcinogenesis, enriching tumor microenvironment (TME) with pro-inflammatory molecules promoting angiogenesis in prostate cancer (PC) and renal cell carcinoma (RCC). Furthermore, cancer cells overexpress complement regulatory proteins, such as CD46, CD55 and CD59, which negatively affect complement pathways for support cancer cells survival. This viewpoint aims to elucidate the ambivalent role of PTX3 and the CS in the context of tumor microenvironment (TME). KW - Pentraxin-3 KW - Complement system KW - Tumor microenvironment KW - Prostate cancer KW - Renal cell carcinoma DO - 10.32604/biocell.2022.020209