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Evaluation of the hepatoprotective and antioxidant effects of Tegillarca granosa flesh body extract against potassium bromide toxicity via targeting the histomorphometry, chromosomal and expressions of TGF-β1, VEGF and COX-2 genes in rats

ALI H. ABU ALMAATY1, BASMA M. HENDAM2, FAYEZ ALTHOBAITI3, EMAN FAYAD3,*, YASMIN M. ABD EL-AZIZ1

1 Department of Zoology, Faculty of Science, Port Said University, Port Said, 42526, Egypt
2 Department of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt
3 Department of Biotechnology, Faculty of Science, Taif University, Taif, 21944, Saudi Arabia

* Corresponding Author:EMAN FAYAD. Email: email

(This article belongs to the Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)

BIOCELL 2022, 46(1), 219-234. https://doi.org/10.32604/biocell.2022.017623

Abstract

The hepatotoxic effect of potassium bromide (KBr) on rat liver tissues were determined, as well as the potential protective effect of Tegillaraca granosa (T. granosa) flesh body extract. Twenty adult male albino rats were equally distributed into four groups; Group (I) treated with physiological saline (control group), Group (II) was orally gavaged by 200 mg/kg of T. granosa body extract day after day, Group (III) was intoxicated by KBr (150 mg/kg bwt day after day orally) and finally, Group (IV) was given a combination of T. granosa flesh body extract plus KBr with similar doses in the second and third groups. At the end of one month, blood, liver tissue and bone marrow samples were collected to be used for the required laboratory examinations. In response to KBr toxicity, there was a significant increase in serum antioxidant biomarkers, which was accompanied by a significant change in hepatocyte ultrastructure and a significant change in carbohydrate and protein levels within the liver organ. In addition, KBr intoxication resulted in a substantial increase in the incidence of chromosomal aberrations such as holes, splits, deletions, fragments, ploidy, and ring chromosomes, as well as significant upregulation of TGF-1, VEGF, and COX-2 gene expression. The hepatotoxic effect of KBr was counteracted by treatment with T. granosa flesh body extract. T. granosa flesh body extract has a curative antioxidant and numerous protective effects against KBr hepatotoxicity.

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APA Style
ALMAATY, A.H.A., HENDAM, B.M., ALTHOBAITI, F., FAYAD, E., EL-AZIZ, Y.M.A. (2022). Evaluation of the hepatoprotective and antioxidant effects of tegillarca granosa flesh body extract against potassium bromide toxicity via targeting the histomorphometry, chromosomal and expressions of TGF-β1, VEGF and COX-2 genes in rats. BIOCELL, 46(1), 219-234. https://doi.org/10.32604/biocell.2022.017623
Vancouver Style
ALMAATY AHA, HENDAM BM, ALTHOBAITI F, FAYAD E, EL-AZIZ YMA. Evaluation of the hepatoprotective and antioxidant effects of tegillarca granosa flesh body extract against potassium bromide toxicity via targeting the histomorphometry, chromosomal and expressions of TGF-β1, VEGF and COX-2 genes in rats. BIOCELL . 2022;46(1):219-234 https://doi.org/10.32604/biocell.2022.017623
IEEE Style
A.H.A. ALMAATY, B.M. HENDAM, F. ALTHOBAITI, E. FAYAD, and Y.M.A. EL-AZIZ, “Evaluation of the hepatoprotective and antioxidant effects of Tegillarca granosa flesh body extract against potassium bromide toxicity via targeting the histomorphometry, chromosomal and expressions of TGF-β1, VEGF and COX-2 genes in rats,” BIOCELL , vol. 46, no. 1, pp. 219-234, 2022. https://doi.org/10.32604/biocell.2022.017623



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This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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