Open Access

REVIEW

miR-153 as biomarker for cancer—functional role as tumor suppressor

by SALONI THAKUR¹, ADESH K. SAINI^2,3, JOYDEEP DAS⁴, VIPIN SAINI³, PARIN BALHARA⁵, JAGPREET S. NANDA^6,*, REENA V. SAINI^2,3,*

1 Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, 173229, India
2 Department of Biotechnology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, 133207, India
3 Maharishi Markandeshwar University, Kumarhatti, Solan, 173229, India
4 Department of Chemistry, Physical Sciences, Mizoram University, Aizawl, 796004, India
5 Department of Kinesiology, California State University, Sacramento, CA 95819, USA
6 Laboratory on the Mechanism and Regulation of Protein Synthesis, Eunice K. Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA

* Corresponding Authors:REENA V. SAINI. Email: ; JAGPREET S. NANDA. Email:

(This article belongs to the Special Issue: Noncoding RNAs & Associated Human Diseases)

BIOCELL 2022, 46(1), 13-26. https://doi.org/10.32604/biocell.2022.016953

Received 13 April 2021; Accepted 09 June 2021; Issue published 28 September 2021

Abstract

MicroRNA-153 (miR-153), belongs to a class of small non-coding RNA. It is a critical regulator of gene expression at the post-transcriptional level which interacts with the functional mRNA at 3’UTR region and suppresses the expression of the mRNA. More recently, it has become apparent that changes in the miR-153 expression lead to invasion, metastasis, angiogenesis and various types of tumor progression. This review summarizes the connection between dysregulation of miR-153 and various types of cancer progression. miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the cancer cell and also show synergistic activity with anticancer drugs. In addition to this, the oncogenic behavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.

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Keywords

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