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Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development
1 Department of Oncology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450007, China
2 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
3Department of Biosciences, Shri Ram Group of College (SRGC), Muzaffarnagar, 251001, India
4 Department of Health Sciences, Novel Global Community Educational Foundation, Sydney, Australia
5Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSUI), Riyadh, 11623, Saudi Arabia
6Department of Biology, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, 11617, Saudi Arabia
* Corresponding Authors:SHAHANAVAJ KHAN. Email: ; ASHWAG SHAMI.Email:
BIOCELL 2022, 46(1), 87-95. https://doi.org/10.32604/biocell.2022.016509
Received 13 March 2021; Accepted 17 May 2021; Issue published 28 September 2021
Abstract
Available reports have confirmed a link between bacterial infection and the progression of different types of cancers, including colon, lungs, and prostate cancer. Here we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum (ER) using in-silico approaches and their possible role in lung cancer etiology. We predicted 48 proteins that target human ER, which may be associated with protein folding and protein-protein interactions during infection. The results showed C. pneumoniae proteins targeting human ER and their implications in lung cancer growth. These targeted proteins may be involved in competitive interactions between host and bacterial proteins, which may change the usual pathway functions and trigger the development of lung cancer. Moreover, C. pneumoniae unfolded protein accumulation in the human ER possibly induces ER stress, consequently activating the unfolded protein response (UPR), and providing a favorable microenvironment for cancer growth. The current study showed the C. pneumoniae protein targeting in ER of host cell and their implication in lung cancer growth. These results may help researchers better manage lung cancer and establish a molecular mechanism for C. pneumoniae lung cancer association.Keywords
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