Open Access

ARTICLE

Antimicrobial activities of three seaweeds extract against some human viral and bacterial pathogens

by JELAN MOFEED^1,2,*, MOHAMED DEYAB³, ABDELNASER MOHAMED³, MAHMOUD MOUSTAFA^4,5, SALLY NEGM^6,7, EMAD EL-BILAWY¹

1 Faculty of Science, King Salman International University, Sinai, Egypt
2 Faculty of Fish Resources, Suez University, Suez, Egypt
3 Faculty of Science, Damietta University, Damietta, Egypt
4 Department of Biology, College of Science, King Khalid University, Abha, 9004, Saudi Arabia
5 Department of Botany and Microbiology, Faculty of Science, South Valley University, Qena, Egypt
6 Life Sciences Department, Faculty of Science and Art, King Khalid University, Mahayel Aseer 61421, Saudi Arabia
7 Unit of Food Bacteriology, Central Laboratory of Food Hygiene, Ministry of Health, Sharkia, 44516, Egypt

* Corresponding Author:JELAN MOFEED. Email:

BIOCELL 2022, 46(1), 247-261. https://doi.org/10.32604/biocell.2022.015966

Received 27 January 2021; Accepted 07 May 2021; Issue published 28 September 2021

Abstract

Microbial infections cause complicated health influences along with bad economic impacts. In the present investigation, three dominant seaweeds namely, Amphiroa anceps, Corallina officinalis and Sargassum filipendula were collected from different Egyptian sites at the Red Sea and Mediterranean Sea during autumn 2019. Organic extracts of the three algae were screened for their antibacterial activity against three pathogenic bacteria Salmonella typhiimurium, Staphylococcus aureus and Escherichia coli, in addition to in vitro antiviral activity against Rotavirus (RV), and Coxsackie virus B3 (CVB3) that cause severe diseases in human. Organic extract of A. anceps, C. officinalis and S. filipendula inhibit E. coli cells by 57.1%, 85.7%, and 91.4%, respectively. The highest level of concentration of the C. officinalis extract (100 µg/mL) inhibits 100% of Staphylococcus aureus cells followed by S. filipendula and A. anceps extract which inhibit 82.5% and 75% of S. aureus. Similarly, the highest concentration of C. officinalis extract inhibits S. typhiimurium by 80%. The extract of A. anceps exhibited a high antiviral effect against RV infection with TI = 22 and virus titers lessened by 2.75 log TCID₅₀ followed by extractions of C. officinalis with TI = 18.3 and virus titers reduced by 2.5 log TCID₅₀. Against CVB3 infection, the extract of A. anceps causes the highest antiviral activity with TI = 15 and reduce the viral titers by 2.5 log TCID₅₀, followed by extractions of C. officinalis with TI = 8.8 and inhibition of virus titers by 1.75 log TCID₅₀. Extract of S. filipendula displayed the lowest antiviral effects against RV and CVB3 infection with TI = 2.4 and 1.4, respectively. The obtained results clarified that the extract of three marine seaweeds maintains a potent antimicrobial activity, making them a future promising source of new antimicrobial drugs.

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