Open Access

REVIEW

Delineating the role of phytocompounds against anti-bacterial drug resistance–An update

by REKHA GAHTORI^1,#, MOSLEH MOHAMMAD ABOMUGHAID^2,#, NIDHI NEGI³, SARAVANAN KRISHNAN⁴, SUGAPRIYA DHANASEKARAN⁵, SOUMYA PANDIT⁶, KANU PRIYA⁶, DILLIP KUMAR BISHI^7,*, RAM PRASAD⁸, PIYUSH KUMAR GUPTA^6,*

1 Department of Biotechnology, Sir J. C. Bose Technical Campus, Kumaun University, Nainital, India
2 Department of Medical Laboratory Sciences, University of Bisha, Bisha, Saudi Arabia
3 Department of Chemistry, Kumaun University, Nainital, India
4 Dhanvantari Nano Ayushadi Pvt., Ltd., Chennai, India
5 Department of Medical Laboratory Sciences (Pathology), College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Riyadh, Saudi Arabia
6 Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida, India
7 Department of Biotechnology, Rama Devi Women’s University, Bhubaneswar, India
8 Department of Botany, Mahatma Gandhi Central University, Motihari, India

* Corresponding Authors: Piyush Kumar Gupta, ; Dillip Kumar Bishi,
# These authors have contributed equally to this work

BIOCELL 2021, 45(6), 1465-1477. https://doi.org/10.32604/biocell.2021.016484

Received 09 March 2021; Accepted 25 April 2021; Issue published 01 September 2021

Abstract

Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization. This kind of problem is not limited to India only, but it is a global concern. Nowadays, many treatments and medicines for bacterial diseases have been developed. However, they possess some drawbacks. Therefore, the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming necessary. Natural products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in bacteria. In recent years, researchers have also focused on new drug discovery from plant-based research. They have looked on various phytocompounds as antibacterial agents. In the current review, we report various classes of secondary metabolites such as phenolic compounds, flavonoids, alkaloids, saponins, terpenes, quinones, and some essential oils that have been used as an antibacterial agent. In addition, we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis.

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